Ki Summary

Reaction Details

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Target

Phosphodiesterase

Ligand

BDBM140091

Substrate/Competitor

n/a

Meas. Tech.

Inhibition Assay

6.5±n/a

Temperature

277.15±n/a K

IC50

1700±n/a nM

Comments

extracted

Citation

Inoue, H; Murafuji, H; Hayashi, Y Thienopyrazole derivative having PDE7 inhibitory activity US Patent US8901315 Publication Date 12/2/2014

More Info.:

Get all data from this article, Assay Method

Phosphodiesterase

Name:

Phosphodiesterase

Synonyms:

Phosphodiesterase 4 (PDE4)

Type:

Protein

Mol. Mass.:

82059.36

Organism:

Mus musculus (Mouse)

Description:

Q8VBU5

Residue:

721

Sequence:

MTAKNSPKEFTASESEVCIKTFKEQMRLELELPKLPGNRPTSPKISPRSSPRNSPCFFRK
LLVNKSIRQRRRFTVAHTCFDVENGPSPGRSPLDPQAGSSSGLVLHAAFPGHSQRRESFL
YRSDSDYDLSPKAMSRNSSLPSEQHGDDLIVTPFAQVLASLRSVRNNFTLLTNLHGAPNK
RSPAASQAPVSRVSLQEESYQKLAMETLEELDWCLDQLETIQTYRSVSEMASNKFKRMLN
RELTHLSEMSRSGNQVSEYISNTFLDKQNDVEIPSPTQKDREKKKKQQLMTQISGVKKLM
HSSSLNNTSISRFGVNTENEDHLAKELEDLNKWGLNIFNVAGYSHNRPLTCIMYAIFQER
DLLKTFKISSDTFVTYMMTLEDHYHSDVAYHNSLHAADVAQSTHVLLSTPALDAVFTDLE
ILAAIFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEEHCDIF
QNLTKKQRQTLRKMVIDMVLATDMSKHMSLLADLKTMVETKKVTSSGVLLLDNYTDRIQV
LRNMVHCADLSNPTKSLELYRQWTDRIMEEFFQQGDKERERGMEISPMCDKHTASVEKSQ
VGFIDYIVHPLWETWADLVQPDAQDILDTLEDNRNWYQSMIPQSPSPPLDERSRDCQGLM
EKFQFELTLEEEDSEGPEKEGEGHSYFSSTKTLCVIDPENRDSLEETDIDIATEDKSPID
T

BDBM140091

n/a

Name

BDBM140091

Synonyms:

US8901315, 171

Type

Small organic molecule

Emp. Form.

C26H39N5O2S

Mol. Mass.

485.685

SMILES

CC(=O)N1CCCN(CC1)[C@H]1CC[C@@H](CC1)NC(=O)c1cc2c(C)nn(C3CCCCC3)c2s1 |r,wU:13.17,wD:10.10,(10.32,1.89,;8.98,1.12,;8.98,-.42,;7.65,1.89,;7.65,3.43,;6.44,4.39,;4.94,4.04,;4.27,2.66,;4.94,1.27,;6.44,.93,;2.73,2.66,;1.96,3.99,;.42,3.99,;-.35,2.66,;.42,1.32,;1.96,1.32,;-1.89,2.66,;-2.66,1.32,;-1.89,-.01,;-4.2,1.32,;-5.1,2.57,;-6.57,2.09,;-8.03,2.57,;-8.8,3.9,;-8.94,1.32,;-8.03,.08,;-8.43,-1.41,;-9.92,-1.81,;-10.32,-3.3,;-9.23,-4.39,;-7.74,-3.99,;-7.34,-2.5,;-6.57,.55,;-5.1,.08,)|

Structure