| Reaction Details |
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 | Report a problem with these data |
| Target | Sodium/calcium exchanger 1 |
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| Ligand | BDBM140727 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Reverse Mode Assay |
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| IC50 | 100±n/a nM |
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| Citation |  Czechtizky, W; Weston, J; Rackelmann, N; Podeschwa, M; Arndt, P; Wirth, K; Goegelein, H; Ritzeler, O; Kraft, V; Bellevergue, P; McCort, G Substituted 2-(chroman-6-yloxy)-thiazoles and their use as pharmaceuticals US Patent US8912224 Publication Date 12/16/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| Sodium/calcium exchanger 1 |
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| Name: | Sodium/calcium exchanger 1 |
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| Synonyms: | CNC | NAC1_HUMAN | NCX1 | SLC8A1 | Sodium/calcium exchanger 1(NCX1) |
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| Type: | Protein |
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| Mol. Mass.: | 108507.88 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P32418 |
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| Residue: | 973 |
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| Sequence: | MYNMRRLSLSPTFSMGFHLLVTVSLLFSHVDHVIAETEMEGEGNETGECTGSYYCKKGVI
LPIWEPQDPSFGDKIARATVYFVAMVYMFLGVSIIADRFMSSIEVITSQEKEITIKKPNG
ETTKTTVRIWNETVSNLTLMALGSSAPEILLSVIEVCGHNFTAGDLGPSTIVGSAAFNMF
IIIALCVYVVPDGETRKIKHLRVFFVTAAWSIFAYTWLYIILSVISPGVVEVWEGLLTFF
FFPICVVFAWVADRRLLFYKYVYKRYRAGKQRGMIIEHEGDRPSSKTEIEMDGKVVNSHV
ENFLDGALVLEVDERDQDDEEARREMARILKELKQKHPDKEIEQLIELANYQVLSQQQKS
RAFYRIQATRLMTGAGNILKRHAADQARKAVSMHEVNTEVTENDPVSKIFFEQGTYQCLE
NCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEFTEGTVVFKPGDTQKEIRVGII
DDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTATVTIFDDDHAGIF
TFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQND
EIVKTISVKVIDDEEYEKNKTFFLEIGEPRLVEMSEKKALLLNELGGFTITGKYLFGQPV
FRKVHAREHPILSTVITIADEYDDKQPLTSKEEEERRIAEMGRPILGEHTKLEVIIEESY
EFKSTVDKLIKKTNLALVVGTNSWREQFIEAITVSAGEDDDDDECGEEKLPSCFDYVMHF
LTVFWKVLFAFVPPTEYWNGWACFIVSILMIGLLTAFIGDLASHFGCTIGLKDSVTAVVF
VALGTSVPDTFASKVAATQDQYADASIGNVTGSNAVNVFLGIGVAWSIAAIYHAANGEQF
KVSPGTLAFSVTLFTIFAFINVGVLLYRRRPEIGGELGGPRTAKLLTSCLFVLLWLLYIF
FSSLEAYCHIKGF
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| BDBM140727 |
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| n/a |
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| Name | BDBM140727 |
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| Synonyms: | US8912224, 159 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H21N3O3S |
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| Mol. Mass. | 419.496 |
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| SMILES | C(NCc1cnc(Oc2ccc3OC(CCc3c2)c2ccccc2)s1)c1ccno1 |
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| Structure | 
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