| Reaction Details |
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 | Report a problem with these data |
| Target | Hormone-sensitive lipase |
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| Ligand | BDBM141543 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 7±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 670±n/a nM |
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| Comments | extracted |
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| Citation |  Zoller, G; Petry, S; Muller, G; Heuer, H; Tennagels, N Azole derivatives in the form of lipase and phospholipase inhibitors US Patent US8921404 Publication Date 12/30/2014 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Hormone-sensitive lipase |
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| Name: | Hormone-sensitive lipase |
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| Synonyms: | Hormone-sensitive lipase | Hormone-sensitive lipase (HSL) | LIPS_RAT | Lipe |
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| Type: | Enzyme |
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| Mol. Mass.: | 116814.94 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P15304 |
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| Residue: | 1068 |
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| Sequence: | MKPRRPISFTREITAMEPSSTSVSRPEWRPEAQQTLTDYPGSRELQEFGIPQKQSLPNEA
TAQQGAEFQQEQGVQQSTLLQKLLTPLAFPVPQQSFPSHKVHSDQQEATSQNGPGAGKVH
TTQKELEHRDEHVGTAESGPAEPPPATEVEATSIAQAVSGPDKKLPTQTDLVSQERAEQS
DPTAQQTPLVQGVKSDQGSLIESGILARLQKLAIQQPSQEWKTFLDCVTESDMEKYLNSS
SKSNPPEPSGGTVIPGTLPSKQKPDCGKMSGYGGKLPHGKKGILQKHKHYWDTASAFSHS
MDLRTMTQSLVALAEDNMAFFSSQGPGETARRLSNVFAGVREQALGLEPTLGQLLGVAHH
FDLDTETPANGYRSLVHTARCCLAHLLHKSRYVASNRRSIFFRASHNLAELEAYLAALTQ
LRALAYYAQRLLTINRPGVLFFEGDEGLSADFLQDYVTLHKGCFYGRCLGFQFTPAIRPF
LQTLSIGLVSFGEHYKRNETGLSVTASSLFTGGRFAIDPELRGAEFERIIQNLDVHFWKA
FWNITEIEVLSSLANMASTTVRVSRLLSLPPEAFEMPLTSDPKLTVTISPPLAHTGPGPV
LARLISYDLREGQDSKMLNSLAKSEGPRLELRPRPQQAPRSRALVVHIHGGGFVAQTSKS
HEPYLKNWAQELGVPIISIDYSLAPEAPFPRALEECFFAYCWAVKHCELLGSTGERICLA
GDSAGGNLCITVSLRAAAYGVRVPDGIMAAYPVTTLQSSASPSRLLSLMDPLLPLSVLSK
CVSAYSGTETEDHFDSDQKALGVMGLVQRDTSLFLRDLRLGASSWLNSFLELSGRKPHKT
PLPATETLRPTDSGRLTESMRRSVSEAALAQPEGLLGTDSLKKLTIKDLSFKGNSEPSDS
PEMSQSMETLGPSTPSDVNFFLRSGNSQEEAETRDDISPMDGIPRVRAAFPDGFHPRRSS
QGVLHMPLYSSPIVKNPFMSPLLAPDVMLKTLPPVHLVACALDPMLDDSVMFARRLKDLG
QPVTLKVVEDLPHGFLSLAALCRETRQAAELCVQRIRLILTPPAAPLT
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| BDBM141543 |
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| n/a |
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| Name | BDBM141543 |
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| Synonyms: | US8921404, 10 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H14ClN3O3 |
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| Mol. Mass. | 295.722 |
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| SMILES | CC1CCN(CC1)C(=O)Oc1noc2nc(Cl)ccc12 |
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| Structure | 
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