Found 119 hits with Last Name = 'muller' and Initial = 'g' Target/Host
(Institution) | Ligand | Target/Host
Links | Ligand
Links | Trg + Lig
Links | Ki
nM | ΔG°
kJ/mole | IC50
nM | Kd
nM | EC50/IC50
nM | koff
s-1 | kon
M-1s-1 | pH | Temp
°C |
|---|
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8117
(Hydroxyethylene Sulfone 17b | N-[(2S,3R,5S)-1-(3-b...)Show SMILES CC(C)C[C@@H](C[C@@H](O)[C@H](Cc1cccc(Br)c1)NC(=O)COc1c(C)cccc1C)S(=O)(=O)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H37BrFNO5S/c1-20(2)15-27(40(37,38)26-13-11-25(33)12-14-26)18-29(35)28(17-23-9-6-10-24(32)16-23)34-30(36)19-39-31-21(3)7-5-8-22(31)4/h5-14,16,20,27-29,35H,15,17-19H2,1-4H3,(H,34,36)/t27-,28-,29+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| MMDB
PC cid
PC sid
PDB
UniChem
Similars
| PDB
Article
PubMed
| 45 | -41.9 | 85 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | 
3D Structure (crystal) |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8123
(Hydroxyethylene Sulfone 18a | N-((1S,2R,4S)-1-(3-b...)Show SMILES CNc1ccc(cc1)S(=O)(=O)[C@@H](CC(C)C)C[C@@H](O)[C@H](Cc1cccc(Br)c1)NC(=O)COc1c(C)cccc1C |r| Show InChI InChI=1S/C32H41BrN2O5S/c1-21(2)16-28(41(38,39)27-14-12-26(34-5)13-15-27)19-30(36)29(18-24-10-7-11-25(33)17-24)35-31(37)20-40-32-22(3)8-6-9-23(32)4/h6-15,17,21,28-30,34,36H,16,18-20H2,1-5H3,(H,35,37)/t28-,29-,30+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 370 | -36.7 | 530 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8124
(Hydroxyethylene Sulfone 18b | N-((1S,2R,4S)-1-(3-b...)Show SMILES CC(C)C[C@@H](C[C@@H](O)[C@H](Cc1cccc(Br)c1)NC(=O)COc1c(C)cccc1C)S(=O)(=O)c1ccc(cc1)N(C)C |r| Show InChI InChI=1S/C33H43BrN2O5S/c1-22(2)17-29(42(39,40)28-15-13-27(14-16-28)36(5)6)20-31(37)30(19-25-11-8-12-26(34)18-25)35-32(38)21-41-33-23(3)9-7-10-24(33)4/h7-16,18,22,29-31,37H,17,19-21H2,1-6H3,(H,35,38)/t29-,30-,31+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 540 | -35.8 | 790 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8118
(Hydroxyethylene Sulfone 17b- | N-[(2R,3S,5R)-1-(3-...)Show SMILES CC(C)C[C@H](C[C@H](O)[C@@H](Cc1cccc(Br)c1)NC(=O)COc1c(C)cccc1C)S(=O)(=O)c1ccc(F)cc1 |r| Show InChI InChI=1S/C31H37BrFNO5S/c1-20(2)15-27(40(37,38)26-13-11-25(33)12-14-26)18-29(35)28(17-23-9-6-10-24(32)16-23)34-30(36)19-39-31-21(3)7-5-8-22(31)4/h5-14,16,20,27-29,35H,15,17-19H2,1-4H3,(H,34,36)/t27-,28-,29+/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 1.40E+3 | -33.4 | 2.00E+3 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8121
((2R)-N-[(2S,3R,5S)-1-(3-bromophenyl)-7-(2,4-dichlo...)Show SMILES O[C@H](C[C@H](CCc1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(F)cc1)[C@H](Cc1cccc(Br)c1)NC(=O)[C@H]1CCCO1 |r| Show InChI InChI=1S/C30H31BrCl2FNO5S/c31-21-4-1-3-19(15-21)16-27(35-30(37)29-5-2-14-40-29)28(36)18-25(11-7-20-6-8-22(32)17-26(20)33)41(38,39)24-12-9-23(34)10-13-24/h1,3-4,6,8-10,12-13,15,17,25,27-29,36H,2,5,7,11,14,16,18H2,(H,35,37)/t25-,27-,28+,29+/m0/s1 | PDB
UniProtKB/SwissProt
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 2.90E+3 | -31.6 | 4.20E+3 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8120
(2-bromo-N-[(2S,3R,5S)-1-(3-bromophenyl)-7-(2,4-dic...)Show SMILES COc1cc(Br)c(cc1OC)C(=O)N[C@@H](Cc1cccc(Br)c1)[C@H](O)C[C@H](CCc1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(F)cc1 |r| Show InChI InChI=1S/C34H32Br2Cl2FNO6S/c1-45-32-18-27(28(36)19-33(32)46-2)34(42)40-30(15-20-4-3-5-22(35)14-20)31(41)17-26(11-7-21-6-8-23(37)16-29(21)38)47(43,44)25-12-9-24(39)10-13-25/h3-6,8-10,12-14,16,18-19,26,30-31,41H,7,11,15,17H2,1-2H3,(H,40,42)/t26-,30-,31+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| 3.10E+3 | -31.4 | 4.50E+3 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8119
(Hydroxyethylene Sulfone 17c | N-[(2S,3R,5S)-1-(3-b...)Show SMILES O[C@H](C[C@H](CCc1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(F)cc1)[C@H](Cc1cccc(Br)c1)NC(=O)COc1ccc(Cl)cc1Cl |r| Show InChI InChI=1S/C33H29BrCl4FNO5S/c34-22-3-1-2-20(14-22)15-30(40-33(42)19-45-32-13-7-24(36)17-29(32)38)31(41)18-27(10-5-21-4-6-23(35)16-28(21)37)46(43,44)26-11-8-25(39)9-12-26/h1-4,6-9,11-14,16-17,27,30-31,41H,5,10,15,18-19H2,(H,40,42)/t27-,30-,31+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
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| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| 7.00E+3 | -29.4 | 1.00E+4 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8122
((2R)-N-[(2R,3S,5R)-1-(3-bromophenyl)-7-(2,4-dichlo...)Show SMILES O[C@@H](C[C@@H](CCc1ccc(Cl)cc1Cl)S(=O)(=O)c1ccc(F)cc1)[C@@H](Cc1cccc(Br)c1)NC(=O)[C@H]1CCCO1 |r| Show InChI InChI=1S/C30H31BrCl2FNO5S/c31-21-4-1-3-19(15-21)16-27(35-30(37)29-5-2-14-40-29)28(36)18-25(11-7-20-6-8-22(32)17-26(20)33)41(38,39)24-12-9-23(34)10-13-24/h1,3-4,6,8-10,12-13,15,17,25,27-29,36H,2,5,7,11,14,16,18H2,(H,35,37)/t25-,27-,28+,29-/m1/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| Article
PubMed
| >4.00E+4 | >-25.1 | >4.00E+4 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
Dimer of Gag-Pol polyprotein [489-587]
(Human immunodeficiency virus type 1) | BDBM8116
(Hydroxyethylene Sulfone 17a | N-[(2S,3R,5S)-1-(3-b...)Show SMILES CC(C)CCS(=O)(=O)[C@@H](C)C[C@@H](O)[C@H](Cc1cccc(Br)c1)NC(=O)CCS(C)(=O)=O |r| Show InChI InChI=1S/C21H34BrNO6S2/c1-15(2)8-11-31(28,29)16(3)12-20(24)19(14-17-6-5-7-18(22)13-17)23-21(25)9-10-30(4,26)27/h5-7,13,15-16,19-20,24H,8-12,14H2,1-4H3,(H,23,25)/t16-,19-,20+/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| >4.00E+4 | >-25.1 | >4.00E+4 | n/a | n/a | n/a | n/a | 5.5 | 25 |
Philipps-Universitat Marburg
| Assay Description
The inhibition assays were performed by mixing enzyme and fluorogenic substrate in the presence of inhibitor compounds. The hydrolysis of the substra... |
J Med Chem 48: 6607-19 (2005)
Article DOI: 10.1021/jm050224y
BindingDB Entry DOI: 10.7270/Q2416V8D |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484445
(CHEMBL1916064)Show InChI InChI=1S/C19H20N2O2/c1-4-23-19-13-15(7-10-18(19)22-3)17(11-12-20)14-5-8-16(21-2)9-6-14/h5-11,13,21H,4H2,1-3H3/b17-11- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 41 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484403
(CHEMBL1916063)Show InChI InChI=1S/C19H20N2O3/c1-4-24-19-12-14(6-8-18(19)23-3)15(9-10-20)13-5-7-17(22-2)16(21)11-13/h5-9,11-12H,4,21H2,1-3H3/b15-9- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 47 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484400
(CHEMBL1916075)Show SMILES Cl.CCOc1cc(ccc1OC)C(=CC#N)c1ccc(OC)c(OC(=O)CN)c1 Show InChI InChI=1S/C21H22N2O5/c1-4-27-19-11-14(5-7-17(19)25-2)16(9-10-22)15-6-8-18(26-3)20(12-15)28-21(24)13-23/h5-9,11-12H,4,13,23H2,1-3H3/b16-9+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 49 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484401
(CHEMBL1916065)Show InChI InChI=1S/C20H22N2O2/c1-5-24-20-14-16(8-11-19(20)23-4)18(12-13-21)15-6-9-17(10-7-15)22(2)3/h6-12,14H,5H2,1-4H3/b18-12- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 52 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484405
(CHEMBL1915853)Show InChI InChI=1S/C20H21NO4/c1-5-25-20-12-14(6-7-19(20)24-4)18(8-9-21)15-10-16(22-2)13-17(11-15)23-3/h6-8,10-13H,5H2,1-4H3/b18-8+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 54 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
DNA damage-binding protein 1/Protein cereblon
(Homo sapiens (Human)) | BDBM65497
(CC-220 (Compound 6) | US9694015, 6.4S)Show SMILES O=C1N(Cc2c1cccc2OCc1ccc(CN2CCOCC2)cc1)[C@H]1CCC(=O)NC1=O Show InChI InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1 | PDB
UniProtKB/SwissProt
GoogleScholar
AffyNet
| Purchase
MCE
PC cid
PC sid
PDB
UniChem
| PDB
Article
PubMed
| n/a | n/a | 60 | n/a | n/a | n/a | n/a | 7.0 | n/a |
Celgene Corporation
| Assay Description
The 6XHis-tagged full length human CRBN bound to full length human DDB1 used in the assay was purified as described elsewhere with the exception that... |
J Med Chem 61: 535-542 (2017)
Article DOI: 10.1021/acs.jmedchem.6b01921
BindingDB Entry DOI: 10.7270/Q2PC30HG |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484442
(CHEMBL1916076)Show SMILES Cl.CCOc1cc(ccc1OC)C(=CC#N)c1ccc(OC)c(OC(=O)[C@H](C)N)c1 |r| Show InChI InChI=1S/C22H24N2O5.ClH/c1-5-28-20-12-15(6-8-18(20)26-3)17(10-11-23)16-7-9-19(27-4)21(13-16)29-22(25)14(2)24;/h6-10,12-14H,5,24H2,1-4H3;1H/t14-;/m0./s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 69 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484428
(CHEMBL1916060)Show InChI InChI=1S/C19H18FNO3/c1-4-24-19-12-14(6-8-18(19)23-3)15(9-10-21)13-5-7-17(22-2)16(20)11-13/h5-9,11-12H,4H2,1-3H3/b15-9- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484449
(CHEMBL1916066)Show SMILES CCOc1cc(ccc1OC)C(=CC#N)c1ccc(OC)c(c1)-n1cccc1 Show InChI InChI=1S/C23H22N2O3/c1-4-28-23-16-18(8-10-22(23)27-3)19(11-12-24)17-7-9-21(26-2)20(15-17)25-13-5-6-14-25/h5-11,13-16H,4H2,1-3H3/b19-11- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484406
(CHEMBL1915854)Show InChI InChI=1S/C21H23NO4/c1-5-25-20-13-15(7-9-18(20)23-3)17(11-12-22)16-8-10-19(24-4)21(14-16)26-6-2/h7-11,13-14H,5-6H2,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 70 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484432
(CHEMBL1916058)Show InChI InChI=1S/C20H21NO3/c1-5-24-20-13-16(7-9-19(20)23-4)17(10-11-21)15-6-8-18(22-3)14(2)12-15/h6-10,12-13H,5H2,1-4H3/b17-10- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 82 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484429
(CHEMBL1915855)Show InChI InChI=1S/C20H21NO4/c1-5-25-20-13-15(7-9-18(20)23-3)16(10-11-21)14-6-8-17(22-2)19(12-14)24-4/h6-10,12-13H,5H2,1-4H3/b16-10- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 83 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484435
(CHEMBL1916062)Show InChI InChI=1S/C19H19NO4/c1-4-24-19-12-14(6-8-18(19)23-3)15(9-10-20)13-5-7-17(22-2)16(21)11-13/h5-9,11-12,21H,4H2,1-3H3/b15-9- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 91 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Rattus norvegicus (Rat)) | BDBM141539
(US8921404, 4)Show InChI InChI=1S/C13H15N3O2S/c1-9-4-7-16(8-5-9)13(17)18-11-10-3-2-6-14-12(10)19-15-11/h2-3,6,9H,4-5,7-8H2,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Sanofi
US Patent
| Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp... |
US Patent US8921404 (2014)
BindingDB Entry DOI: 10.7270/Q24748KQ |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Rattus norvegicus (Rat)) | BDBM141538
(US8921404, 3)Show InChI InChI=1S/C14H12ClF3N2O3/c15-9-1-2-10-11(7-9)23-19-12(10)22-13(21)20-5-3-8(4-6-20)14(16,17)18/h1-2,7-8H,3-6H2 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Sanofi
US Patent
| Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp... |
US Patent US8921404 (2014)
BindingDB Entry DOI: 10.7270/Q24748KQ |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Rattus norvegicus (Rat)) | BDBM141540
(US8921404, 5)Show InChI InChI=1S/C14H16N2O2S/c1-10-6-8-16(9-7-10)14(17)18-13-11-4-2-3-5-12(11)19-15-13/h2-5,10H,6-9H2,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| US Patent
| n/a | n/a | 100 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Sanofi
US Patent
| Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp... |
US Patent US8921404 (2014)
BindingDB Entry DOI: 10.7270/Q24748KQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484402
(CHEMBL1916059)Show InChI InChI=1S/C19H19NO3/c1-4-23-19-13-15(8-9-18(19)22-3)17(10-11-20)14-6-5-7-16(12-14)21-2/h5-10,12-13H,4H2,1-3H3/b17-10- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 110 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484434
(CHEMBL1916074)Show SMILES CCOc1cc(ccc1OC)C(=CC#N)c1ccc(OC)c(OC(=O)N(C)C)c1 Show InChI InChI=1S/C22H24N2O5/c1-6-28-20-13-15(7-9-18(20)26-4)17(11-12-23)16-8-10-19(27-5)21(14-16)29-22(25)24(2)3/h7-11,13-14H,6H2,1-5H3/b17-11+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Rattus norvegicus (Rat)) | BDBM141536
(US8921404, 1)Show InChI InChI=1S/C14H15ClN2O3/c1-9-4-6-17(7-5-9)14(18)19-13-11-3-2-10(15)8-12(11)20-16-13/h2-3,8-9H,4-7H2,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Sanofi
US Patent
| Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp... |
US Patent US8921404 (2014)
BindingDB Entry DOI: 10.7270/Q24748KQ |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Rattus norvegicus (Rat)) | BDBM141537
(US8921404, 2)Show InChI InChI=1S/C13H15N3O3/c1-9-4-7-16(8-5-9)13(17)18-12-10-3-2-6-14-11(10)19-15-12/h2-3,6,9H,4-5,7-8H2,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Sanofi
US Patent
| Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp... |
US Patent US8921404 (2014)
BindingDB Entry DOI: 10.7270/Q24748KQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484404
(CHEMBL1916077)Show SMILES Cl.CCOc1cc(ccc1OC)C(=CC#N)c1ccc(OC)c(OC(=O)[C@@H](N)C(C)C)c1 |r| Show InChI InChI=1S/C24H28N2O5.ClH/c1-6-30-21-13-16(7-9-19(21)28-4)18(11-12-25)17-8-10-20(29-5)22(14-17)31-24(27)23(26)15(2)3;/h7-11,13-15,23H,6,26H2,1-5H3;1H/t23-;/m0./s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 120 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50216304
(CHEMBL313439)Show InChI InChI=1S/C20H18N2O4/c1-3-26-18-12-13(8-9-17(18)25-2)16(10-11-21)22-19(23)14-6-4-5-7-15(14)20(22)24/h4-9,12,16H,3,10H2,1-2H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 130 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of PDE4 enzyme from U937 cells |
Bioorg Med Chem Lett 8: 2669-74 (1998)
BindingDB Entry DOI: 10.7270/Q2BK1FJH |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484446
(CHEMBL1915843)Show SMILES COc1cc(OC)cc(c1)C(=CC(C)=O)c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C20H22O5/c1-13(21)8-18(14-6-7-19(24-4)20(11-14)25-5)15-9-16(22-2)12-17(10-15)23-3/h6-12H,1-5H3/b18-8- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 140 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484407
(CHEMBL1916073)Show SMILES Cl.CCOc1cc(ccc1OC)C(=CC#N)c1ccc(OC)c(NC(=O)[C@H](C)N)c1 |r| Show InChI InChI=1S/C22H25N3O4.ClH/c1-5-29-21-13-16(7-9-20(21)28-4)17(10-11-23)15-6-8-19(27-3)18(12-15)25-22(26)14(2)24;/h6-10,12-14H,5,24H2,1-4H3,(H,25,26);1H/t14-;/m0./s1 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484408
(CHEMBL1915827)Show InChI InChI=1S/C19H19NO4/c1-21-15-9-14(10-16(12-15)22-2)17(7-8-20)13-5-6-18(23-3)19(11-13)24-4/h5-7,9-12H,1-4H3/b17-7- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 150 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484409
(CHEMBL1915832)Show InChI InChI=1S/C18H17NO3/c1-20-15-6-4-5-13(11-15)16(9-10-19)14-7-8-17(21-2)18(12-14)22-3/h4-9,11-12H,1-3H3/b16-9- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 160 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484436
(CHEMBL1915831)Show InChI InChI=1S/C18H17NO3/c1-20-15-7-4-13(5-8-15)16(10-11-19)14-6-9-17(21-2)18(12-14)22-3/h4-10,12H,1-3H3/b16-10- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 190 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484424
(CHEMBL1916061)Show SMILES CCOc1cc(ccc1OC)C(=CC#N)c1ccc(cc1)S(C)(=O)=O Show InChI InChI=1S/C19H19NO4S/c1-4-24-19-13-15(7-10-18(19)23-2)17(11-12-20)14-5-8-16(9-6-14)25(3,21)22/h5-11,13H,4H2,1-3H3/b17-11- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 200 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50216301
(CHEMBL88475)Show SMILES CCOc1cc(ccc1OC)C(CC(=O)OC)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C21H21NO6/c1-4-28-18-11-13(9-10-17(18)26-2)16(12-19(23)27-3)22-20(24)14-7-5-6-8-15(14)21(22)25/h5-11,16H,4,12H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 230 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of PDE4 enzyme from U937 cells |
Bioorg Med Chem Lett 8: 2669-74 (1998)
BindingDB Entry DOI: 10.7270/Q2BK1FJH |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Rattus norvegicus (Rat)) | BDBM141544
(US8921404, 11)Show InChI InChI=1S/C14H17N3O3/c1-9-5-7-17(8-6-9)14(18)19-13-11-4-3-10(2)15-12(11)20-16-13/h3-4,9H,5-8H2,1-2H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 260 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Sanofi
US Patent
| Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp... |
US Patent US8921404 (2014)
BindingDB Entry DOI: 10.7270/Q24748KQ |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484433
(3,3-Bis(3,4-Dimethoxyphenyl)Acrylonitrile | CHEMBL...)Show SMILES [#6]-[#8]-c1ccc(cc1-[#8]-[#6])-[#6](=[#6]/C#N)\c1ccc(-[#8]-[#6])c(-[#8]-[#6])c1 Show InChI InChI=1S/C19H19NO4/c1-21-16-7-5-13(11-18(16)23-3)15(9-10-20)14-6-8-17(22-2)19(12-14)24-4/h5-9,11-12H,1-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 310 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50216299
(CHEMBL315529)Show SMILES COc1ccc(cc1OC1CCCC1)C(CC#N)N1C(=O)c2ccccc2C1=O Show InChI InChI=1S/C23H22N2O4/c1-28-20-11-10-15(14-21(20)29-16-6-2-3-7-16)19(12-13-24)25-22(26)17-8-4-5-9-18(17)23(25)27/h4-5,8-11,14,16,19H,2-3,6-7,12H2,1H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of PDE4 enzyme from U937 cells |
Bioorg Med Chem Lett 8: 2669-74 (1998)
BindingDB Entry DOI: 10.7270/Q2BK1FJH |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484437
(CHEMBL1915825)Show InChI InChI=1S/C19H19NO4/c1-21-15-9-14(10-16(12-15)22-2)17(7-8-20)13-5-6-18(23-3)19(11-13)24-4/h5-7,9-12H,1-4H3/b17-7+ | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 350 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484410
(CHEMBL1916068)Show SMILES [#6]-[#6]-[#8]-c1cc(ccc1-[#8]-[#6])-[#6](=[#6](\F)F)\c1ccc(-[#8]-[#6])c(-[#8])c1 Show InChI InChI=1S/C18H18F2O4/c1-4-24-16-10-12(6-8-15(16)23-3)17(18(19)20)11-5-7-14(22-2)13(21)9-11/h5-10,21H,4H2,1-3H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 360 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484425
(CHEMBL1916067)Show InChI InChI=1S/C18H20O4/c1-5-22-18-11-14(7-9-17(18)21-4)12(2)13-6-8-16(20-3)15(19)10-13/h6-11,19H,2,5H2,1,3-4H3 | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
Tumor necrosis factor
(Homo sapiens (Human)) | BDBM50052612
(3-(5-Amino-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-...)Show SMILES COC(=O)CC(N1C(=O)c2ccc(N)cc2C1=O)c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C20H20N2O6/c1-26-16-7-4-11(8-17(16)27-2)15(10-18(23)28-3)22-19(24)13-6-5-12(21)9-14(13)20(22)25/h4-9,15H,10,21H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Similars
| Article
PubMed
| n/a | n/a | 380 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of TNF-alpha production in LPS stimulated human PBMCs |
J Med Chem 39: 3238-40 (1996)
Article DOI: 10.1021/jm9603328
BindingDB Entry DOI: 10.7270/Q2V40T9Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484411
(CHEMBL1916072)Show SMILES Cl.CCOc1cc(ccc1OC)C(=CC#N)c1ccc(OC)c(NC(=O)CN)c1 Show InChI InChI=1S/C21H23N3O4/c1-4-28-20-12-15(6-8-19(20)27-3)16(9-10-22)14-5-7-18(26-2)17(11-14)24-21(25)13-23/h5-9,11-12H,4,13,23H2,1-3H3,(H,24,25)/b16-9- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
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antibodypedia
GoogleScholar
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| PC cid
PC sid
UniChem
| Article
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| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM14361
((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)Show InChI InChI=1S/C16H21NO3/c1-19-14-7-6-11(12-9-16(18)17-10-12)8-15(14)20-13-4-2-3-5-13/h6-8,12-13H,2-5,9-10H2,1H3,(H,17,18) | PDB
UniProtKB/SwissProt
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| Purchase
CHEMBL
MCE
PC cid
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PDB
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Similars
| PDB
PubMed
| n/a | n/a | 400 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of phosphodiesterase 4 from U937 cells |
Bioorg Med Chem Lett 8: 2669-74 (1998)
BindingDB Entry DOI: 10.7270/Q2BK1FJH |
More data for this
Ligand-Target Pair |
3D Structure (crystal) |
Tumor necrosis factor
(Homo sapiens (Human)) | BDBM50052602
(3-(4-Amino-1,3-dioxo-1,3-dihydro-isoindol-2-yl)-3-...)Show SMILES COC(=O)CC(N1C(=O)c2cccc(N)c2C1=O)c1ccc(OC)c(OC)c1 Show InChI InChI=1S/C20H20N2O6/c1-26-15-8-7-11(9-16(15)27-2)14(10-17(23)28-3)22-19(24)12-5-4-6-13(21)18(12)20(22)25/h4-9,14H,10,21H2,1-3H3 | PDB
MMDB
Reactome pathway
KEGG
UniProtKB/SwissProt
B.MOAD
DrugBank
antibodypedia
GoogleScholar
AffyNet
| CHEMBL
PC cid
PC sid
UniChem
Patents
Similars
| Article
PubMed
| n/a | n/a | 450 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of TNF-alpha production in LPS stimulated human PBMCs |
J Med Chem 39: 3238-40 (1996)
Article DOI: 10.1021/jm9603328
BindingDB Entry DOI: 10.7270/Q2V40T9Q |
More data for this
Ligand-Target Pair | |
cAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D
(Homo sapiens (Human)) | BDBM50484443
(CHEMBL1916070)Show InChI InChI=1S/C19H23NO3/c1-5-15(13-7-9-17(21-3)16(20)11-13)14-8-10-18(22-4)19(12-14)23-6-2/h5,7-12H,6,20H2,1-4H3/b15-5- | PDB
UniProtKB/SwissProt
antibodypedia
antibodypedia
antibodypedia
antibodypedia
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
| Article
PubMed
| n/a | n/a | 590 | n/a | n/a | n/a | n/a | n/a | n/a |
Celgene Corporation
Curated by ChEMBL
| Assay Description
Inhibition of human PDE4 expressed in U937 cells using [3H]cAMP as substrate after 30 mins |
Bioorg Med Chem 19: 6356-74 (2011)
Article DOI: 10.1016/j.bmc.2011.08.068
BindingDB Entry DOI: 10.7270/Q2Z60RXK |
More data for this
Ligand-Target Pair | |
Hormone-sensitive lipase
(Rattus norvegicus (Rat)) | BDBM141543
(US8921404, 10)Show InChI InChI=1S/C13H14ClN3O3/c1-8-4-6-17(7-5-8)13(18)19-12-9-2-3-10(14)15-11(9)20-16-12/h2-3,8H,4-7H2,1H3 | KEGG
UniProtKB/SwissProt
GoogleScholar
AffyNet
| PC cid
PC sid
UniChem
Similars
| US Patent
| n/a | n/a | 670 | n/a | n/a | n/a | n/a | 7.0 | 37 |
Sanofi
US Patent
| Assay Description
To prepare the substrate, 25-50 uCi of [3H]trioleoylglycerol (in toluene), 6.8 umol of unlabeled trioleoylglycerol and 0.6 mg of phospholipids (phosp... |
US Patent US8921404 (2014)
BindingDB Entry DOI: 10.7270/Q24748KQ |
More data for this
Ligand-Target Pair | |
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