| Reaction Details |
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 | Report a problem with these data |
| Target | Microtubule-associated protein tau |
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| Ligand | BDBM142850 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| pH | 6.5±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 10.1±n/a nM |
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| Comments | extracted |
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| Citation |  Sakai, D; Nakayama, K; Watanabe, K Pyrimidone compounds US Patent US8940738 Publication Date 1/27/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Microtubule-associated protein tau |
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| Name: | Microtubule-associated protein tau |
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| Synonyms: | MAPT | TAU | TAU_BOVIN | Tau Protein Kinase 1 (TPK1) |
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| Type: | Protein |
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| Mol. Mass.: | 46340.02 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | P29172 |
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| Residue: | 448 |
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| Sequence: | MAEPRQEFDVMEDHAQGDYTLQDQEGDMDPGLKESPLQTPADDGSEEPGSETSDAKSTPT
AEDATAPLVDEGAPGEQAAAQAPAEIPEGTAAEEAGIGDTSNLEDQAAGHVTQARMVSKG
KDGTGPDDKKTKGADGKPGTKIATPRGAAPPGQKGQANATRIPAKTTPTPKTSPATMQVQ
KKPPPAGAKSERGESGKSGDRSGYSSPGSPGTPGSRSRTPSLPTPPTREPKKVAVVRTPP
KSPSAAKSRLQAAPGPMPDLKNVKSKIGSTENLKHQPGGGKVQIINKKLDLSNVQSKCGS
KDNIKHVPGGGSVQIVYKPVDLSKVTSKCGSLGNIHHKPGGGQVEVKSEKLDFKDRVQSK
IGSLDNITHVPGGGNKKIETHKLTFRENAKAKTDHGAEIVYKSPVVSGDTSPRHLSNVSS
TGSIDMVDSPQLATLADEVSASLAKQGL
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| BDBM142850 |
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| n/a |
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| Name | BDBM142850 |
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| Synonyms: | US8940738, 6 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H18FN7O |
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| Mol. Mass. | 391.4016 |
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| SMILES | Cn1c(nc(cc1=O)-c1ncncc1F)N1CCNC(C1)c1ccc(cc1)[N+]#[C-] |
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| Structure | 
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