| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM147015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IMAP-FP (Molecular Devices Trade Mark Technology) Endpoint Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 1992±n/a nM |
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| Comments | extracted |
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| Citation |  Brain, CT; Cho, YS; Giraldes, JW; Lagu, B; Levell, JR; Luzzio, MJ; Perez, LB; Wang, Y; Yang, F Pyrrolopyrimidine compounds as inhibitors of CDK4/6 US Patent US8957074 Publication Date 2/17/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM147015 |
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| n/a |
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| Name | BDBM147015 |
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| Synonyms: | US8957074, 54 |
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| Type | Small organic molecule |
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| Emp. Form. | C31H36N8O2 |
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| Mol. Mass. | 552.6699 |
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| SMILES | CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)C(=O)N3CC4CCC(C3)N4)nc2n1-c1cccc(c1)C(C)(C)C |TLB:18:20:27:23.24| |
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| Structure | 
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