Ki Summary

Reaction Details

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Target

Kappa-type opioid receptor

Ligand

BDBM147192

Substrate/Competitor

n/a

Meas. Tech.

Radioligand Dose-Displacement Binding Assay

7.4±n/a

Temperature

298.15±n/a K

125.99±n/a nM

Comments

extracted

Citation

Kyle, DJ; Tafesse, L; Zhou, X 7,8-cyclicmorphinan analogs US Patent US8957084 Publication Date 2/17/2015

More Info.:

Get all data from this article, Assay Method

Kappa-type opioid receptor

Name:

Kappa-type opioid receptor

Synonyms:

Type:

G Protein-Coupled Receptor (GPCR)

Mol. Mass.:

42648.76

Organism:

Homo sapiens (Human)

Description:

P41145

Residue:

380

Sequence:

MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPV
IITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYL
MNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINI
CIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVL
IIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALG
STSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRV
RNTVQDPAYLRDIDGMNKPV

BDBM147192

n/a

Name

BDBM147192

Synonyms:

US8957084, 5

Type

Small organic molecule

Emp. Form.

C27H35NO2

Mol. Mass.

405.5723

SMILES

COc1ccc2C[C@@H]3[C@@H]4[C@H]5C6CCC(CC6)[C@H]5C(=O)C[C@]4(CCN3CC3CC3)c2c1 |r,wU:16.18,9.17,7.26,wD:20.32,8.22,TLB:24:23:6.5.28:8,(-5.77,-5.44,;-4.23,-5.44,;-3.46,-4.1,;-4.23,-2.77,;-3.46,-1.44,;-1.92,-1.44,;-1.15,-.1,;.39,-.1,;1.16,-1.44,;2.7,-1.44,;3.47,-.1,;5.01,-.1,;5.77,-1.44,;5.01,-2.77,;5.01,-1.71,;4.56,-.63,;3.47,-2.77,;2.7,-4.1,;3.47,-5.44,;1.16,-4.1,;.39,-2.77,;-.38,-1.44,;-.38,1.23,;1.16,1.23,;1.93,2.56,;1.16,3.9,;1.16,5.44,;-.18,4.67,;-1.15,-2.77,;-1.92,-4.1,)|

Structure