| Reaction Details |
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 | Report a problem with these data |
| Target | Cyclin-dependent kinase 1 |
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| Ligand | BDBM148237 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | IMAP-FPT (Molecular Devices Trade Mark Technology) Endpoint Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | >15000±n/a nM |
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| Comments | extracted |
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| Citation |  Brain, CT; Sung, MJ; Lagu, B Pyrrolopyrimidine compounds and their uses US Patent US8962630 Publication Date 2/24/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Cyclin-dependent kinase 1 |
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| Name: | Cyclin-dependent kinase 1 |
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| Synonyms: | CDC2 | CDC28A | CDK1 | CDK1_HUMAN | CDKN1 | Cell division control protein 2 homolog | Cell division protein kinase 1 | Cyclin-dependent kinase 1 (CDK1) | P34CDC2 | p34 protein kinase |
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| Type: | Enzyme Subunit |
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| Mol. Mass.: | 34101.08 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P06493 |
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| Residue: | 297 |
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| Sequence: | MEDYTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELRH
PNIVSLQDVLMQDSRLYLIFEFLSMDLKKYLDSIPPGQYMDSSLVKSYLYQILQGIVFCH
SRRVLHRDLKPQNLLIDDKGTIKLADFGLARAFGIPIRVYTHEVVTLWYRSPEVLLGSAR
YSTPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNEVWPEVESLQDYKNT
FPKWKPGSLASHVKNLDENGLDLLSKMLIYDPAKRISGKMALNHPYFNDLDNQIKKM
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| BDBM148237 |
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| n/a |
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| Name | BDBM148237 |
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| Synonyms: | US8962630, 46 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H36N8O3 |
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| Mol. Mass. | 508.6158 |
|---|
| SMILES | CN(C)C(=O)c1cc2cnc(Nc3ccc(cn3)N3CCN(C[C@@H](O)CO)CC3)nc2n1C1CCCC1 |r| |
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| Structure | 
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