| Reaction Details |
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 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
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| Ligand | BDBM50446177 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Luminescent Kinase Assay |
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| IC50 | 4.00±n/a nM |
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| Citation |  Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent US9518026 Publication Date 12/13/2016 |
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| More Info.: | Get all data from this article, Assay Method |
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| Calmodulin-domain protein kinase 1 |
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| Name: | Calmodulin-domain protein kinase 1 |
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| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 57248.42 |
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| Organism: | Toxoplasma gondii |
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| Description: | n/a |
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| Residue: | 507 |
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| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
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| BDBM50446177 |
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| n/a |
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| Name | BDBM50446177 |
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| Synonyms: | CHEMBL3108991 | US9518026, Example 18 | US9956214, Compound 18 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H13F3N4O |
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| Mol. Mass. | 334.2958 |
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| SMILES | NC(=O)c1c(N)n(CC(F)(F)F)nc1-c1ccc2ccccc2c1 |
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| Structure | 
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