| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
|---|
| Ligand | BDBM286305 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Luminescent Kinase Assay |
|---|
| IC50 | 6.00±n/a nM |
|---|
| Citation |  Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent US9518026 Publication Date 12/13/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calmodulin-domain protein kinase 1 |
|---|
| Name: | Calmodulin-domain protein kinase 1 |
|---|
| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57248.42 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | n/a |
|---|
| Residue: | 507 |
|---|
| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
|
|
|
|---|
| BDBM286305 |
|---|
| n/a |
|---|
| Name | BDBM286305 |
|---|
| Synonyms: | 5-amino-3-(2-ethoxyquinolin-6- yl)-1-(3-hydroxy-3-methylbutan- 2-yl)-1H-pyrazole-4-carboxamide MS (ESI) (M + H)+ = 384.8 | US9518026, Example 98 | US9956214, Compound 1636 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H25N5O3 |
|---|
| Mol. Mass. | 383.4442 |
|---|
| SMILES | CCOc1ccc2cc(ccc2n1)-c1nn(C(C)C(C)(C)O)c(N)c1C(N)=O |
|---|
| Structure | 
|
|---|
Search and Browse
