| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Calmodulin-domain protein kinase 1 |
|---|
| Ligand | BDBM286307 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Luminescent Kinase Assay |
|---|
| IC50 | 12.0±n/a nM |
|---|
| Citation |  Fan, E; Van Voorhis, WC; Zhang, Z; Huang, W; Ojo, KK 5-aminopyrazole-4-carboxamide inhibitors of CDPK1 from T. gondii and C. parvum US Patent US9518026 Publication Date 12/13/2016 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Calmodulin-domain protein kinase 1 |
|---|
| Name: | Calmodulin-domain protein kinase 1 |
|---|
| Synonyms: | Calmodulin-domain protein kinase 1 | Calmodulin-domain protein kinase 1 (CDPK1) | Calmodulin-domain protein kinase, putative |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 57248.42 |
|---|
| Organism: | Toxoplasma gondii |
|---|
| Description: | n/a |
|---|
| Residue: | 507 |
|---|
| Sequence: | MGQQESTLGGAAGEPRSRGHAAGTSGGPGDHLHATPGMFVQHSTAIFSDRYKGQRVLGKG
SFGEVILCKDKITGQECAVKVISKRQVKQKTDKESLLREVQLLKQLDHPNIMKLYEFFED
KGYFYLVGEVYTGGELFDEIISRKRFSEVDAARIIRQVLSGITYMHKNKIVHRDLKPENL
LLESKSKDANIRIIDFGLSTHFEASKKMKDKIGTAYYIAPEVLHGTYDEKCDVWSTGVIL
YILLSGCPPFNGANEYDILKKVEKGKYTFELPQWKKVSESAKDLIRKMLTYVPSMRISAR
DALDHEWIQTYTKEQISVDVPSLDNAILNIRQFQGTQKLAQAALLYMGSKLTSQDETKEL
TAIFHKMDKNGDGQLDRAELIEGYKELMRMKGQDASMLDASAVEHEVDQVLDAVDFDKNG
YIEYSEFVTVAMDRKTLLSRERLERAFRMFDSDNSGKISSTELATIFGVSDVDSETWKSV
LSEVDKNNDGEVDFDEFQQMLLKLCGN
|
|
|
|---|
| BDBM286307 |
|---|
| n/a |
|---|
| Name | BDBM286307 |
|---|
| Synonyms: | 5-amino-3-(7-ethoxyquinolin-3- yl)-1-(1-methylcyclohexyl)-1H- pyrazole-4-carboxamide MS (ESI) (M + H)+ = 394.7 | US9518026, Example 100 | US9956214, Compound 1640 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27N5O2 |
|---|
| Mol. Mass. | 393.4821 |
|---|
| SMILES | CCOc1ccc2cc(cnc2c1)-c1nn(c(N)c1C(N)=O)C1(C)CCCCC1 |
|---|
| Structure | 
|
|---|
Search and Browse
