Reaction Details |
| Report a problem with these data |
Target | Proteinase-activated receptor 4 |
---|
Ligand | BDBM286440 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | FLIPR Assay |
---|
Temperature | 298.15±n/a K |
---|
IC50 | 0.740±n/a nM |
---|
Comments | extracted |
---|
Citation | Martel, A; Tremblay, F; Marinier, A; Priestley, ES; Posy, SL; Lawrence, RM; Miller, MM Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9518064 Publication Date 12/13/2016 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Proteinase-activated receptor 4 |
---|
Name: | Proteinase-activated receptor 4 |
Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
Type: | Protein |
Mol. Mass.: | 41145.16 |
Organism: | Homo sapiens (Human) |
Description: | Q96RI0 |
Residue: | 385 |
Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
|
|
|
BDBM286440 |
---|
n/a |
---|
Name | BDBM286440 |
Synonyms: | US9518064, Example 56 |
Type | Small organic molecule |
Emp. Form. | C26H19ClN4O4S |
Mol. Mass. | 518.971 |
SMILES | COc1nn2cc(nc2s1)-c1cc2c(OCc3cccc(c3)-c3ccc(Cl)nc3)cc(OC)cc2o1 |
Structure |
|