Reaction Details |
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Target | Proteinase-activated receptor 4 |
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Ligand | BDBM286493 |
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Substrate/Competitor | n/a |
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Meas. Tech. | FLIPR Assay |
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Temperature | 298.15±n/a K |
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IC50 | 0.360±n/a nM |
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Comments | extracted |
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Citation | Martel, A; Tremblay, F; Marinier, A; Priestley, ES; Posy, SL; Lawrence, RM; Miller, MM Imidazothiadiazole and imidazopyridazine derivatives as protease activated receptor 4 (PAR4) inhibitors for treating platelet aggregation US Patent US9518064 Publication Date 12/13/2016 |
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More Info.: | Get all data from this article, Assay Method |
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Proteinase-activated receptor 4 |
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Name: | Proteinase-activated receptor 4 |
Synonyms: | Coagulation factor II receptor-like 3 | F2RL3 | PAR-4 | PAR4 | PAR4_HUMAN | Proteinase-activated receptor 4 | Proteinase-activated receptor 4 (PAR4) | Thrombin receptor-like 3 |
Type: | Protein |
Mol. Mass.: | 41145.16 |
Organism: | Homo sapiens (Human) |
Description: | Q96RI0 |
Residue: | 385 |
Sequence: | MWGRLLLWPLVLGFSLSGGTQTPSVYDESGSTGGGDDSTPSILPAPRGYPGQVCANDSDT
LELPDSSRALLLGWVPTRLVPALYGLVLVVGLPANGLALWVLATQAPRLPSTMLLMNLAA
ADLLLALALPPRIAYHLRGQRWPFGEAACRLATAALYGHMYGSVLLLAAVSLDRYLALVH
PLRARALRGRRLALGLCMAAWLMAAALALPLTLQRQTFRLARSDRVLCHDALPLDAQASH
WQPAFTCLALLGCFLPLLAMLLCYGATLHTLAASGRRYGHALRLTAVVLASAVAFFVPSN
LLLLLHYSDPSPSAWGNLYGAYVPSLALSTLNSCVDPFIYYYVSAEFRDKVRAGLFQRSP
GDTVASKASAEGGSRGMGTHSSLLQ
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BDBM286493 |
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n/a |
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Name | BDBM286493 |
Synonyms: | (S)-2-(1-Fluoroethyl)-6-(6-methoxy-4-((6-(4-methoxytetrahydro-2H-pyran-4-yl)pyridin-2-yl)methoxy)benzofuran-2-yl)imidazo[2,1-b][1,3,4]thiadiazole | US9518064, Example 112 |
Type | Small organic molecule |
Emp. Form. | C27H27FN4O5S |
Mol. Mass. | 538.59 |
SMILES | COc1cc(OCc2cccc(n2)C2(CCOCC2)OC)c2cc(oc2c1)-c1cn2nc(sc2n1)[C@H](C)F |r| |
Structure |
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