Reaction Details |
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Target | Acetylcholinesterase |
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Ligand | BDBM152515 |
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Substrate/Competitor | n/a |
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Meas. Tech. | In Vitro AChE Inhibition Assay |
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pH | 8±n/a |
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Ki | 5.45e+3± 9.1e+2 nM |
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IC50 | 4.363e+4± 5e+1 nM |
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Km | 2160±3250 nM |
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Comments | extracted |
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Citation | Piplani, P; Danta, CC Design and synthesis of newer potential 4-(N-acetylamino)phenol derived piperazine derivatives as potential cognition enhancers. Bioorg Chem60:64-73 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Acetylcholinesterase |
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Name: | Acetylcholinesterase |
Synonyms: | ACES_MOUSE | Acetylcholinesterase (AChE) | Acetylcholinesterase (mouse AChE) | Acetylcholinesterase precursor | Ache |
Type: | Enzyme |
Mol. Mass.: | 68165.65 |
Organism: | Mus musculus (mouse) |
Description: | n/a |
Residue: | 614 |
Sequence: | MRPPWYPLHTPSLAFPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGVLDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPASPTPVLIWIYGGGFYSGAASLDVYDGRFLAQVEGAVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
IACLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPEALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPNDPRDSKSPQWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
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BDBM152515 |
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n/a |
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Name | BDBM152515 |
Synonyms: | N-(4-(2-(4-(4-fluorophenyl)piperazin-1-yl)-2-oxoethoxy)phenyl)acetamide (1d) |
Type | Small organic molecule |
Emp. Form. | C20H22FN3O3 |
Mol. Mass. | 371.4054 |
SMILES | CC(=O)Nc1ccc(OCC(=O)N2CCN(CC2)c2ccc(F)cc2)cc1 |
Structure |
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