| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase |
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| Ligand | BDBM152586 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Beta-glucuronidase Inhibition Assay |
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| IC50 | 4.84e+4± 1.25e+3 nM |
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| Citation |  Taha, M; Ismail, NH; Imran, S; Selvaraj, M; Rashwan, H; Farhanah, FU; Rahim, F; Kesavanarayanan, KS; Ali, M Synthesis of benzimidazole derivatives as potent ß-glucuronidase inhibitors. Bioorg Chem61:36-44 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase |
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| Name: | Beta-glucuronidase |
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| Synonyms: | Beta-glucuronidase | Beta-glucuronidase (β-glucuronidase) | EMBL:AAI33416.1 | Ensembl:ENSBTAP00000000941 | Ensembl:ENSBTAP00000000941} | GUSB |
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| Type: | Protein |
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| Mol. Mass.: | 74467.69 |
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| Organism: | Bos taurus (Bovine) |
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| Description: | EC 3.2.1.31, bovine liver |
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| Residue: | 652 |
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| Sequence: | MLRGSAGAWAVLGPLLWGCGLSLLQGGMLYPRESRSRERKELDGLWSFRADFSDNRRQGF
EQQWYRAPLRESGPTLDMPVPSSFNDVGQDGQLRSFVGWVWYEREITLPQRWTEDLGTRV
VLRIGSAHYYAIVWVNGVHVLEHEGGHLPFEADISKLVQSGPLSSCRITIAINNTLSPHT
LPPGTILYKTDPSMYPKGYFVQNTKFDFFNYAGLHRSVLLYTTPTTYIDDITVTTDMDQD
IGLVNYQIIVQGSDHFQVDVSLLDEEGKVMAKGAGAEGQLQVPSAHLWWPYLMHEHPAYL
YSLEVKLTAQTAVGPVSDFYTLPVGIRTVAVTKSQFLINGKPFYFRGVNKHEDADIRGKG
FDWPLLVKDFNLLRWLGANAFRTSHYPYSEEVLQLCDRYGIVVIDESPGVGIVLVESFSN
VSLQHHLEVMEEMIRRDKNHPAVVMWSLANEPASFLKPAGYYFKTLIAHTKALDPSRPVT
FVTNTNYEADLGAPYVDIICVNSYYSWYHDYGHMEVIQLQLATQFENWYKAYQKPMIQSE
YGADAIEGFHEDPPLMFSEEYQKGLLQQYHVVLDQKRKEYVVGELIWNFADFMTNQSPVR
MIGNRKGIFTRQRQPKSAAFLLRERYWKLANETRYQRSAVTSQCVGSGLFTV
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| BDBM152586 |
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| n/a |
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| Name | BDBM152586 |
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| Synonyms: | D-Saccharic acid 1,4 lactone | D-Saccharic acid 1,4-lactone | D-Saccharic acid 1,4-lactone | D-saccharic acid-1,4-lactone |
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| Type | Small organic molecule |
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| Emp. Form. | C6H8O7 |
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| Mol. Mass. | 192.1235 |
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| SMILES | OC(C1OC(=O)C(O)C1O)C(O)=O |
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| Structure | 
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