| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-lactamase |
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| Ligand | BDBM152733 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Steady State Kinetics |
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| pH | 7.2±n/a |
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| Ki | 2e+2±n/a nM |
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| Comments | extracted |
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| Citation |  Hazra, S; Kurz, SG; Wolff, K; Nguyen, L; Bonomo, RA; Blanchard, JS Kinetic and Structural Characterization of the Interaction of 6-Methylidene Penem 2 with the ß-Lactamase from Mycobacterium tuberculosis. Biochemistry54:5657-64 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-lactamase |
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| Name: | Beta-lactamase |
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| Synonyms: | BLAC_MYCTO | Class A beta-lactamase BlaC (BlaC) | blaA | blaC |
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| Type: | Protein |
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| Mol. Mass.: | 32565.98 |
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| Organism: | Mycobacterium tuberculosis H37Rv |
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| Description: | n/a |
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| Residue: | 307 |
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| Sequence: | MRNRGFGRRELLVAMAMLVSVTGCARHASGARPASTTLPAGADLADRFAELERRYDARLG
VYVPATGTTAAIEYRADERFAFCSTFKAPLVAAVLHQNPLTHLDKLITYTSDDIRSISPV
AQQHVQTGMTIGQLCDAAIRYSDGTAANLLLADLGGPGGGTAAFTGYLRSLGDTVSRLDA
EEPELNRDPPGDERDTTTPHAIALVLQQLVLGNALPPDKRALLTDWMARNTTGAKRIRAG
FPADWKVIDKTGTGDYGRANDIAVVWSPTGVPYVVAVMSDRAGGGYDAEPREALLAEAAT
CVAGVLA
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| BDBM152733 |
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| n/a |
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| Name | BDBM152733 |
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| Synonyms: | Penem 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C13H10N3O3S2 |
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| Mol. Mass. | 320.367 |
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| SMILES | [O-]C(=O)C1=CSC2N1C(=O)\C2=C\c1cc2CCSCn2n1 |t:3| |
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| Structure | 
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