| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Membrane metallo-endopeptidase-like 1 |
|---|
| Ligand | BDBM138393 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibition Assay |
|---|
| pH | 7.4±n/a |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 2.4±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Foo, SY Method of treating contrast-induced nephropathy US Patent US8993631 Publication Date 3/31/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Membrane metallo-endopeptidase-like 1 |
|---|
| Name: | Membrane metallo-endopeptidase-like 1 |
|---|
| Synonyms: | Endopeptidase (NEP) | MELL1 | MMEL1 | MMEL1_HUMAN | MMEL2 | NEP2 | Neutral endopeptidase (NEP) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 89358.76 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q495T6 |
|---|
| Residue: | 779 |
|---|
| Sequence: | MGKSEGPVGMVESAGRAGQKRPGFLEGGLLLLLLLVTAALVALGVLYADRRGKQLPRLAS
RLCFLQEERTFVKRKPRGIPEAQEVSEVCTTPGCVIAAARILQNMDPTTEPCDDFYQFAC
GGWLRRHVIPETNSRYSIFDVLRDELEVILKAVLENSTAKDRPAVEKARTLYRSCMNQSV
IEKRGSQPLLDILEVVGGWPVAMDRWNETVGLEWELERQLALMNSQFNRRVLIDLFIWND
DQNSSRHIIYIDQPTLGMPSREYYFNGGSNRKVREAYLQFMVSVATLLREDANLPRDSCL
VQEDMVQVLELETQLAKATVPQEERHDVIALYHRMGLEELQSQFGLKGFNWTLFIQTVLS
SVKIKLLPDEEVVVYGIPYLQNLENIIDTYSARTIQNYLVWRLVLDRIGSLSQRFKDTRV
NYRKALFGTMVEEVRWRECVGYVNSNMENAVGSLYVREAFPGDSKSMVRELIDKVRTVFV
ETLDELGWMDEESKKKAQEKAMSIREQIGHPDYILEEMNRRLDEEYSNLNFSEDLYFENS
LQNLKVGAQRSLRKLREKVDPNLWIIGAAVVNAFYSPNRNQIVFPAGILQPPFFSKEQPQ
ALNFGGIGMVIGHEITHGFDDNGRNFDKNGNMMDWWSNFSTQHFREQSECMIYQYGNYSW
DLADEQNVNGFNTLGENIADNGGVRQAYKAYLKWMAEGGKDQQLPGLDLTHEQLFFINYA
QVWCGSYRPEFAIQSIKTDVHSPLKYRVLGSLQNLAAFADTFHCARGTPMHPKERCRVW
|
|
|
|---|
| BDBM138393 |
|---|
| n/a |
|---|
| Name | BDBM138393 |
|---|
| Synonyms: | US8877786, Example 3-7 | US8993631, 32-4 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H20ClN3O5 |
|---|
| Mol. Mass. | 429.854 |
|---|
| SMILES | C[C@H](N[C@@H](Cc1ccc(cc1)-c1cccc(Cl)c1)C(=O)Nc1cc(O)no1)C(O)=O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
