| Reaction Details |
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 | Report a problem with these data |
| Target | Epithelial discoidin domain-containing receptor 1 |
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| Ligand | BDBM286724 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Binding Activity |
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| Temperature | 298.15±n/a K |
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| IC50 | 12.0±n/a nM |
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| Comments | extracted |
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| Citation |  Murata, T; Kawada, H; Niizuma, S; Hara, S; Hada, K; Shimada, H; Tanaka, H; Mio, T Quinazolinedione derivative US Patent US9567304 Publication Date 2/14/2017 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epithelial discoidin domain-containing receptor 1 |
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| Name: | Epithelial discoidin domain-containing receptor 1 |
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| Synonyms: | CAK | DDR1 | DDR1_HUMAN | Discoidin domain receptor 1 (DDR1) | Discoidin domain-containing receptor 1 (DDR1) | Discoidin receptor tyrosine kinase | EDDR1 | Epithelial discoidin domain receptor 1 | Epithelial discoidin domain receptor 1 (DDR1) | Epithelial discoidin domain-containing receptor 1 | Epithelial discoidin domain-containing receptor 1 (DDR1) | HGK2 | Mammary carcinoma kinase 10 | NEP | NTRK4 | PTK3A | Protein-tyrosine kinase RTK 6 | RTK6 | TRKE | Tyrosine-protein kinase CAK |
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| Type: | Tyrosine-protein kinase |
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| Mol. Mass.: | 101130.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q08345 |
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| Residue: | 913 |
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| Sequence: | MGPEALSSLLLLLLVASGDADMKGHFDPAKCRYALGMQDRTIPDSDISASSSWSDSTAAR
HSRLESSDGDGAWCPAGSVFPKEEEYLQVDLQRLHLVALVGTQGRHAGGLGKEFSRSYRL
RYSRDGRRWMGWKDRWGQEVISGNEDPEGVVLKDLGPPMVARLVRFYPRADRVMSVCLRV
ELYGCLWRDGLLSYTAPVGQTMYLSEAVYLNDSTYDGHTVGGLQYGGLGQLADGVVGLDD
FRKSQELRVWPGYDYVGWSNHSFSSGYVEMEFEFDRLRAFQAMQVHCNNMHTLGARLPGG
VECRFRRGPAMAWEGEPMRHNLGGNLGDPRARAVSVPLGGRVARFLQCRFLFAGPWLLFS
EISFISDVVNNSSPALGGTFPPAPWWPPGPPPTNFSSLELEPRGQQPVAKAEGSPTAILI
GCLVAIILLLLLIIALMLWRLHWRRLLSKAERRVLEEELTVHLSVPGDTILINNRPGPRE
PPPYQEPRPRGNPPHSAPCVPNGSALLLSNPAYRLLLATYARPPRGPGPPTPAWAKPTNT
QAYSGDYMEPEKPGAPLLPPPPQNSVPHYAEADIVTLQGVTGGNTYAVPALPPGAVGDGP
PRVDFPRSRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPD
ATKNARNDFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLED
KAAEGAPGDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTI
KIADFGMSRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLC
RAQPFGQLTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQ
LHRFLAEDALNTV
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| BDBM286724 |
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| n/a |
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| Name | BDBM286724 |
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| Synonyms: | 7-((S)-3- Aminomethyl- pyrrolidin-1- ylmethyl)-6-bromo- 3-(5-chloro-2- ethanesulfonyl- benzyl)-1H- quinazoline-2,4- dione | US9567304, Compound E-12 |
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| Type | Small organic molecule |
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| Emp. Form. | C23H26BrClN4O4S |
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| Mol. Mass. | 569.899 |
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| SMILES | CCS(=O)(=O)c1ccc(Cl)cc1Cn1c(=O)[nH]c2cc(CN3CC[C@@H](CN)C3)c(Br)cc2c1=O |r| |
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| Structure | 
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