Reaction Details |
| Report a problem with these data |
Target | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
---|
Ligand | BDBM153710 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | KinEASE Assay |
---|
IC50 | 1.60e+5± 4.4e+4 nM |
---|
Citation | Fang, Z; Simard, JR; Plenker, D; Nguyen, HD; Phan, T; Wolle, P; Baumeister, S; Rauh, D Discovery of inter-domain stabilizers-a novel assay system for allosteric akt inhibitors. ACS Chem Biol10:279-88 (2015) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
---|
Name: | RAC-alpha serine/threonine-protein kinase [E49C,C296S,C310S,C344S] |
Synonyms: | AKT1 | AKT1_HUMAN | PKB | Protein kinase B (Akt1 E49C, C296S, C310S and C344S ) | RAC |
Type: | Protein |
Mol. Mass.: | 55608.09 |
Organism: | Homo sapiens (Human) |
Description: | Human Akt1 containing mutations E49C, C296S, C310S and C344S |
Residue: | 480 |
Sequence: | MSDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRCAPLNNFSVAQC
QLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWTTAIQTVADGLKKQEEEEMDF
RSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKI
LKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLS
RERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLSKEGI
KDGATMKTFSGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMSGRLPFYNQDHEKLFEL
ILMEEIRFPRTLGPEAKSLLSGLLKKDPKQRLGGGSEDAKEIMQHRFFAGIVWQHVYEKK
LSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA
|
|
|
BDBM153710 |
---|
n/a |
---|
Name | BDBM153710 |
Synonyms: | 7-(4-methylphenyl)-5-phenyl-N-(pyridin-3-ylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (8b) |
Type | Small organic molecule |
Emp. Form. | C25H21N5 |
Mol. Mass. | 391.4677 |
SMILES | Cc1ccc(cc1)-n1cc(-c2ccccc2)c2c(NCc3cccnc3)ncnc12 |
Structure |
|