| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Ligand | BDBM155438 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Enzyme Assay |
|---|
| pH | 8±n/a |
|---|
| IC50 | 3820±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Thunuguntla, SS; Subramanya, H; Kunnam, SR; Sanivaru Vijay, SR; Bingi, C; Kusanur, R; Schwarz, M; Arlt, M Dihydroorotate dehydrogenase inhibitors US Patent US9006454 Publication Date 4/14/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Name: | Dihydroorotate dehydrogenase (quinone), mitochondrial |
|---|
| Synonyms: | DHODH | DHOdehase | Dihydroorotate dehydrogenase | Dihydroorotate dehydrogenase (DHODH) | Dihydroorotate dehydrogenase, mitochondrial | Dihydroorotate oxidase | Dihydroorotate oxidase (DHODH) | PYRD_HUMAN |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 42881.33 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q02127 |
|---|
| Residue: | 395 |
|---|
| Sequence: | MAWRHLKKRAQDAVIILGGGGLLFASYLMATGDERFYAEHLMPTLQGLLDPESAHRLAVR
FTSLGLLPRARFQDSDMLEVRVLGHKFRNPVGIAAGFDKHGEAVDGLYKMGFGFVEIGSV
TPKPQEGNPRPRVFRLPEDQAVINRYGFNSHGLSVVEHRLRARQQKQAKLTEDGLPLGVN
LGKNKTSVDAAEDYAEGVRVLGPLADYLVVNVSSPNTAGLRSLQGKAELRRLLTKVLQER
DGLRRVHRPAVLVKIAPDLTSQDKEDIASVVKELGIDGLIVTNTTVSRPAGLQGALRSET
GGLSGKPLRDLSTQTIREMYALTQGRVPIIGVGGVSSGQDALEKIRAGASLVQLYTALTF
WGPPVVGKVKRELEALLKEQGFGGVTDAIGADHRR
|
|
|
|---|
| BDBM155438 |
|---|
| n/a |
|---|
| Name | BDBM155438 |
|---|
| Synonyms: | US9006454, I75 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H15N3O2 |
|---|
| Mol. Mass. | 329.352 |
|---|
| SMILES | Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1ccc(nc1)-c1ccccc1 |
|---|
| Structure | 
|
|---|
Search and Browse
