Compile Data Set for Download or QSAR

Found 111 hits Enz. Inhib. hit(s) with all data for entry = 6878   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kJ/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155481 (US9006454, I123) Show SMILES Cc1cc(C(O)=O)c2n(C)c(nc2c1)-c1c(F)c(F)c(-c2ccccc2)c(F)c1F |(-7.81,-2.13,;-6.47,-1.36,;-6.47,.18,;-5.14,.95,;-5.14,2.49,;-3.8,3.26,;-6.47,3.26,;-3.8,.18,;-2.34,.65,;-1.57,1.99,;-1.43,-.59,;-2.34,-1.84,;-3.8,-1.36,;-5.14,-2.13,;.11,-.59,;.88,.74,;.11,2.08,;2.42,.74,;3.19,2.08,;3.19,-.59,;4.73,-.59,;5.5,-1.93,;7.04,-1.93,;7.81,-.59,;7.04,.74,;5.5,.74,;2.42,-1.93,;3.19,-3.26,;.88,-1.93,;.11,-3.26,)| Show InChI InChI=1S/C22H14F4N2O2/c1-10-8-12(22(29)30)20-13(9-10)27-21(28(20)2)15-18(25)16(23)14(17(24)19(15)26)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155498 (US9006454, I140) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(c(F)c1F)-c1ccccc1F |(-7.81,-2.13,;-6.47,-1.36,;-6.47,.18,;-5.14,.95,;-5.14,2.49,;-6.47,3.26,;-3.8,3.26,;-3.8,.18,;-2.34,.65,;-1.43,-.59,;-2.34,-1.84,;-3.8,-1.36,;-5.14,-2.13,;.11,-.59,;.88,.74,;.11,2.08,;2.42,.74,;3.19,2.08,;3.19,-.59,;2.42,-1.92,;3.19,-3.26,;.88,-1.92,;.11,-3.26,;4.73,-.59,;5.5,-1.93,;7.04,-1.93,;7.81,-.59,;7.04,.74,;5.5,.74,;4.73,2.08,)| Show InChI InChI=1S/C21H11F5N2O2/c1-8-6-10(21(29)30)19-12(7-8)27-20(28-19)14-17(25)15(23)13(16(24)18(14)26)9-4-2-3-5-11(9)22/h2-7H,1H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	3.5	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155440 (US9006454, I82) Show SMILES Cc1ccc(C)n1-c1c(F)c(F)c(-c2nc3cc(C)cc(C(O)=O)c3[nH]2)c(F)c1F |(5.22,-3.17,;5.99,-1.84,;7.45,-1.36,;7.45,.18,;5.99,.65,;5.22,1.99,;5.08,-.59,;3.54,-.59,;2.77,.74,;3.54,2.08,;1.23,.74,;.46,2.08,;.46,-.59,;-1.08,-.59,;-1.98,-1.84,;-3.45,-1.36,;-4.78,-2.13,;-6.12,-1.36,;-7.45,-2.13,;-6.12,.18,;-4.78,.95,;-4.78,2.49,;-3.45,3.26,;-6.12,3.26,;-3.45,.18,;-1.98,.65,;1.23,-1.93,;.46,-3.26,;2.77,-1.93,;3.54,-3.26,)| Show InChI InChI=1S/C21H15F4N3O2/c1-8-6-11(21(29)30)18-12(7-8)26-20(27-18)13-14(22)16(24)19(17(25)15(13)23)28-9(2)4-5-10(28)3/h4-7H,1-3H3,(H,26,27)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	5.60	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155421 (US9006454, I41) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccccc2)c(F)c1F Show InChI InChI=1S/C21H12F4N2O2/c1-9-7-11(21(28)29)19-12(8-9)26-20(27-19)14-17(24)15(22)13(16(23)18(14)25)10-5-3-2-4-6-10/h2-8H,1H3,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	6.80	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155484 (US9006454, I126) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1c(F)c(F)c(-c2cccc(F)c2)c(F)c1F Show InChI InChI=1S/C21H11F5N2O2/c1-8-5-11(21(29)30)19-12(6-8)27-20(28-19)14-17(25)15(23)13(16(24)18(14)26)9-3-2-4-10(22)7-9/h2-7H,1H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	8.86	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155462 (US9006454, I104) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1c(F)c(F)c(-c2cccc(O)c2)c(F)c1F Show InChI InChI=1S/C21H12F4N2O3/c1-8-5-11(21(29)30)19-12(6-8)26-20(27-19)14-17(24)15(22)13(16(23)18(14)25)9-3-2-4-10(28)7-9/h2-7,28H,1H3,(H,26,27)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.5	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155463 (US9006454, I105) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1c(F)c(F)c(-c2cccc(OCc3ccccc3)c2)c(F)c1F Show InChI InChI=1S/C28H18F4N2O3/c1-14-10-18(28(35)36)26-19(11-14)33-27(34-26)21-24(31)22(29)20(23(30)25(21)32)16-8-5-9-17(12-16)37-13-15-6-3-2-4-7-15/h2-12H,13H2,1H3,(H,33,34)(H,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	13.6	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155454 (US9006454, I96) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1c(F)c(F)c(-c2ccc(O)cc2)c(F)c1F Show InChI InChI=1S/C21H12F4N2O3/c1-8-6-11(21(29)30)19-12(7-8)26-20(27-19)14-17(24)15(22)13(16(23)18(14)25)9-2-4-10(28)5-3-9/h2-7,28H,1H3,(H,26,27)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	16	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155489 (US9006454, I131) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(c(F)c1F)-c1ccccc1F |(-7.14,3.26,;-5.8,2.49,;-4.47,3.26,;-5.8,.95,;-7.14,.18,;-7.14,-1.36,;-5.8,-2.13,;-4.47,-1.36,;-3.01,-1.84,;-2.1,-.59,;-3.01,.65,;-4.47,.18,;-.56,-.59,;.21,.74,;-.56,2.08,;1.75,.74,;2.52,2.08,;2.52,-.59,;1.75,-1.92,;2.52,-3.26,;.21,-1.92,;-.56,-3.26,;4.06,-.59,;4.83,-1.93,;6.37,-1.93,;7.14,-.59,;6.37,.74,;4.83,.74,;4.06,2.08,)| Show InChI InChI=1S/C20H9F5N2O2/c21-10-6-2-1-4-8(10)12-14(22)16(24)13(17(25)15(12)23)19-26-11-7-3-5-9(20(28)29)18(11)27-19/h1-7H,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	18	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155487 (US9006454, I129) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(-c2cc(F)cc(F)c2)c(F)c1F Show InChI InChI=1S/C20H8F6N2O2/c21-8-4-7(5-9(22)6-8)12-14(23)16(25)13(17(26)15(12)24)19-27-11-3-1-2-10(20(29)30)18(11)28-19/h1-6H,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	20	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155504 (US9006454, I146) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2cc(F)cc(F)c2)c(F)c1F Show InChI InChI=1S/C21H10F6N2O2/c1-7-2-11(21(30)31)19-12(3-7)28-20(29-19)14-17(26)15(24)13(16(25)18(14)27)8-4-9(22)6-10(23)5-8/h2-6H,1H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	21	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155465 (US9006454, I107) Show SMILES OC(=O)c1cccc2nc([nH]c12)-c1c(F)c(F)c(-c2cccc(OCc3ccccc3)c2)c(F)c1F Show InChI InChI=1S/C27H16F4N2O3/c28-21-19(15-8-4-9-16(12-15)36-13-14-6-2-1-3-7-14)22(29)24(31)20(23(21)30)26-32-18-11-5-10-17(27(34)35)25(18)33-26/h1-12H,13H2,(H,32,33)(H,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	26	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155483 (US9006454, I125) Show SMILES OC(=O)c1cccc2nc([nH]c12)-c1c(F)c(F)c(-c2cccc(F)c2)c(F)c1F Show InChI InChI=1S/C20H9F5N2O2/c21-9-4-1-3-8(7-9)12-14(22)16(24)13(17(25)15(12)23)19-26-11-6-2-5-10(20(28)29)18(11)27-19/h1-7H,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	28.2	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155499 (US9006454, I141) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2cccnc2)c(F)c1F Show InChI InChI=1S/C20H11F4N3O2/c1-8-5-10(20(28)29)18-11(6-8)26-19(27-18)13-16(23)14(21)12(15(22)17(13)24)9-3-2-4-25-7-9/h2-7H,1H3,(H,26,27)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	32	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155411 (US9006454, I21) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(-c2ccccc2)c(F)c1F Show InChI InChI=1S/C20H10F4N2O2/c21-14-12(9-5-2-1-3-6-9)15(22)17(24)13(16(14)23)19-25-11-8-4-7-10(20(27)28)18(11)26-19/h1-8H,(H,25,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	38	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155485 (US9006454, I127) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccc(OCc3ccccc3)cc2)c(F)c1F Show InChI InChI=1S/C28H18F4N2O3/c1-14-11-18(28(35)36)26-19(12-14)33-27(34-26)21-24(31)22(29)20(23(30)25(21)32)16-7-9-17(10-8-16)37-13-15-5-3-2-4-6-15/h2-12H,13H2,1H3,(H,33,34)(H,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	48	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155497 (US9006454, I139) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccsc2)c(F)c1F Show InChI InChI=1S/C19H10F4N2O2S/c1-7-4-9(19(26)27)17-10(5-7)24-18(25-17)12-15(22)13(20)11(14(21)16(12)23)8-2-3-28-6-8/h2-6H,1H3,(H,24,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	50	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155443 (US9006454, I85) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(c(F)c1F)-c1ccc(NC(=O)C2CCCN2)cc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	56	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155458 (US9006454, I100) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1c(F)c(F)c(c(F)c1F)-c1ccccc1OCc1ccccc1 |(-7.81,-4.21,;-6.47,-3.44,;-6.47,-1.9,;-5.14,-1.13,;-5.14,.41,;-3.8,1.18,;-6.47,1.18,;-3.8,-1.9,;-2.34,-1.42,;-1.43,-2.67,;-2.34,-3.91,;-3.8,-3.44,;-5.14,-4.21,;.11,-2.67,;.88,-1.33,;.11,,;2.42,-1.33,;3.19,,;3.19,-2.67,;2.42,-4,;3.19,-5.33,;.88,-4,;.11,-5.33,;4.73,-2.67,;5.5,-4,;7.04,-4,;7.81,-2.67,;7.04,-1.33,;5.5,-1.33,;4.73,,;5.5,1.33,;4.73,2.67,;5.5,4,;4.73,5.33,;3.19,5.33,;2.42,4,;3.19,2.67,)| Show InChI InChI=1S/C28H18F4N2O3/c1-14-11-17(28(35)36)26-18(12-14)33-27(34-26)21-24(31)22(29)20(23(30)25(21)32)16-9-5-6-10-19(16)37-13-15-7-3-2-4-8-15/h2-12H,13H2,1H3,(H,33,34)(H,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	60	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155452 (US9006454, I94) Show SMILES Cc1cc(C(O)=O)c2n(CCO)c(nc2c1)-c1c(F)c(F)c(-c2ccc(O)cc2)c(F)c1F |(-8.58,-2.83,;-7.24,-2.06,;-7.24,-.52,;-5.91,.25,;-5.91,1.79,;-7.24,2.56,;-4.57,2.56,;-4.57,-.52,;-3.11,-.04,;-2.34,1.29,;-3.11,2.62,;-2.34,3.96,;-2.2,-1.29,;-3.11,-2.54,;-4.57,-2.06,;-5.91,-2.83,;-.66,-1.29,;.11,.04,;-.66,1.38,;1.65,.04,;2.42,1.38,;2.42,-1.29,;3.96,-1.29,;4.73,-2.62,;6.27,-2.62,;7.04,-1.29,;8.58,-1.29,;6.27,.04,;4.73,.04,;1.65,-2.62,;2.42,-3.96,;.11,-2.62,;-.66,-3.96,)| Show InChI InChI=1S/C23H16F4N2O4/c1-10-8-13(23(32)33)21-14(9-10)28-22(29(21)6-7-30)16-19(26)17(24)15(18(25)20(16)27)11-2-4-12(31)5-3-11/h2-5,8-9,30-31H,6-7H2,1H3,(H,32,33)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155441 (US9006454, I83) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccc(CN3CCCCC3)cc2)c(F)c1F Show InChI InChI=1S/C27H23F4N3O2/c1-14-11-17(27(35)36)25-18(12-14)32-26(33-25)20-23(30)21(28)19(22(29)24(20)31)16-7-5-15(6-8-16)13-34-9-3-2-4-10-34/h5-8,11-12H,2-4,9-10,13H2,1H3,(H,32,33)(H,35,36)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	78	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155468 (US9006454, I110) Show SMILES Cc1ccc(C)n1-c1c(F)c(F)c(-c2nc3cccc(C(O)=O)c3[nH]2)c(F)c1F |(4.55,-3.17,;5.32,-1.84,;6.78,-1.36,;6.78,.18,;5.32,.65,;4.55,1.99,;4.41,-.59,;2.87,-.59,;2.1,.74,;2.87,2.08,;.56,.74,;-.21,2.08,;-.21,-.59,;-1.75,-.59,;-2.65,-1.84,;-4.12,-1.36,;-5.45,-2.13,;-6.78,-1.36,;-6.78,.18,;-5.45,.95,;-5.45,2.49,;-4.12,3.26,;-6.78,3.26,;-4.12,.18,;-2.65,.65,;.56,-1.92,;-.21,-3.26,;2.1,-1.92,;2.87,-3.26,)| Show InChI InChI=1S/C20H13F4N3O2/c1-8-6-7-9(2)27(8)18-15(23)13(21)12(14(22)16(18)24)19-25-11-5-3-4-10(20(28)29)17(11)26-19/h3-7H,1-2H3,(H,25,26)(H,28,29)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	110	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155471 (US9006454, I113) Show SMILES Cc1cc(C(O)=O)c2nc(-c3c(F)c(F)c(-c4ccccc4)c(F)c3F)n(C)c2c1 |(-7.81,-2.13,;-6.47,-1.36,;-6.47,.18,;-5.14,.95,;-5.14,2.49,;-3.8,3.26,;-6.47,3.26,;-3.8,.18,;-2.34,.65,;-1.43,-.59,;.11,-.59,;.88,.74,;.11,2.08,;2.42,.74,;3.19,2.08,;3.19,-.59,;4.73,-.59,;5.5,-1.93,;7.04,-1.93,;7.81,-.59,;7.04,.74,;5.5,.74,;2.42,-1.92,;3.19,-3.26,;.88,-1.92,;.11,-3.26,;-2.34,-1.84,;-1.57,-3.17,;-3.8,-1.36,;-5.14,-2.13,)| Show InChI InChI=1S/C22H14F4N2O2/c1-10-8-12(22(29)30)20-13(9-10)28(2)21(27-20)15-18(25)16(23)14(17(24)19(15)26)11-6-4-3-5-7-11/h3-9H,1-2H3,(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	116	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155492 (US9006454, I134) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccc(F)cc2)c(F)c1F Show InChI InChI=1S/C21H11F5N2O2/c1-8-6-11(21(29)30)19-12(7-8)27-20(28-19)14-17(25)15(23)13(16(24)18(14)26)9-2-4-10(22)5-3-9/h2-7H,1H3,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	118	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155469 (US9006454, I111) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1cnn(Cc2ccccc2)c1 Show InChI InChI=1S/C25H20N4O2/c1-16-11-21(25(30)31)23-22(12-16)27-24(28-23)19-9-7-18(8-10-19)20-13-26-29(15-20)14-17-5-3-2-4-6-17/h2-13,15H,14H2,1H3,(H,27,28)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	155	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155413 (US9006454, I25) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1ccc(cc1F)-c1ccccc1F Show InChI InChI=1S/C21H14F2N2O2/c1-11-8-15(21(26)27)19-18(9-11)24-20(25-19)14-7-6-12(10-17(14)23)13-4-2-3-5-16(13)22/h2-10H,1H3,(H,24,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	172	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155425 (US9006454, I48) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)cc(cc1F)-c1ccccc1 Show InChI InChI=1S/C21H14F2N2O2/c1-11-7-14(21(26)27)19-17(8-11)24-20(25-19)18-15(22)9-13(10-16(18)23)12-5-3-2-4-6-12/h2-10H,1H3,(H,24,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	177	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155486 (US9006454, I128) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(c(F)c1F)-c1cccc(F)c1F |(-7.14,3.26,;-5.8,2.49,;-4.47,3.26,;-5.8,.95,;-7.14,.18,;-7.14,-1.36,;-5.8,-2.13,;-4.47,-1.36,;-3.01,-1.84,;-2.1,-.59,;-3.01,.65,;-4.47,.18,;-.56,-.59,;.21,.74,;-.56,2.08,;1.75,.74,;2.52,2.08,;2.52,-.59,;1.75,-1.92,;2.52,-3.26,;.21,-1.92,;-.56,-3.26,;4.06,-.59,;4.83,-1.93,;6.37,-1.93,;7.14,-.59,;6.37,.74,;7.14,2.08,;4.83,.74,;4.06,2.08,)| Show InChI InChI=1S/C20H8F6N2O2/c21-9-5-1-3-7(13(9)22)11-14(23)16(25)12(17(26)15(11)24)19-27-10-6-2-4-8(20(29)30)18(10)28-19/h1-6H,(H,27,28)(H,29,30)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	209	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155506 (US9006454, I148) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(-c2cccc(OC(F)(F)F)c2)c(F)c1F Show InChI InChI=1S/C21H9F7N2O3/c22-14-12(8-3-1-4-9(7-8)33-21(26,27)28)15(23)17(25)13(16(14)24)19-29-11-6-2-5-10(20(31)32)18(11)30-19/h1-7H,(H,29,30)(H,31,32)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	218	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155436 (US9006454, I68) Show SMILES OC(=O)c1cc(F)cc2[nH]c(nc12)-c1c(F)cc(cc1F)-c1ccccc1 Show InChI InChI=1S/C20H11F3N2O2/c21-12-8-13(20(26)27)18-16(9-12)24-19(25-18)17-14(22)6-11(7-15(17)23)10-4-2-1-3-5-10/h1-9H,(H,24,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	276	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155494 (US9006454, I136) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(-c2cccnc2)c(F)c1F Show InChI InChI=1S/C19H9F4N3O2/c20-13-11(8-3-2-6-24-7-8)14(21)16(23)12(15(13)22)18-25-10-5-1-4-9(19(27)28)17(10)26-18/h1-7H,(H,25,26)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	282	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155405 (US9006454, I14) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H16N2O2/c1-13-11-17(21(24)25)19-18(12-13)22-20(23-19)16-9-7-15(8-10-16)14-5-3-2-4-6-14/h2-12H,1H3,(H,22,23)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	304	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155503 (US9006454, I145) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccc(F)c(F)c2)c(F)c1F Show InChI InChI=1S/C21H10F6N2O2/c1-7-4-9(21(30)31)19-12(5-7)28-20(29-19)14-17(26)15(24)13(16(25)18(14)27)8-2-3-10(22)11(23)6-8/h2-6H,1H3,(H,28,29)(H,30,31)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	314	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155439 (US9006454, I76) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1ccc(cc1)-c1c(F)cccc1F Show InChI InChI=1S/C21H14F2N2O2/c1-11-9-14(21(26)27)19-17(10-11)24-20(25-19)13-7-5-12(6-8-13)18-15(22)3-2-4-16(18)23/h2-10H,1H3,(H,24,25)(H,26,27)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	344	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155475 (US9006454, I117) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1ccc(O)cc1 Show InChI InChI=1S/C21H16N2O3/c1-12-10-17(21(25)26)19-18(11-12)22-20(23-19)15-4-2-13(3-5-15)14-6-8-16(24)9-7-14/h2-11,24H,1H3,(H,22,23)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	350	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155399 (US9006454, I3 | US9006454, I5) Show SMILES COc1cccc(c1)-c1ccc(-c2nc3c(cccc3[nH]2)C(O)=O)c(F)c1 Show InChI InChI=1S/C21H15FN2O3/c1-27-14-5-2-4-12(10-14)13-8-9-15(17(22)11-13)20-23-18-7-3-6-16(21(25)26)19(18)24-20/h2-11H,1H3,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	368	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155414 (US9006454, I26) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1ccc(cc1)-c1ccccc1F Show InChI InChI=1S/C21H15FN2O2/c1-12-10-16(21(25)26)19-18(11-12)23-20(24-19)14-8-6-13(7-9-14)15-4-2-3-5-17(15)22/h2-11H,1H3,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	373	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155490 (US9006454, I132) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(-c2ccc(OCc3ccccc3)cc2)c(F)c1F Show InChI InChI=1S/C27H16F4N2O3/c28-21-19(15-9-11-16(12-10-15)36-13-14-5-2-1-3-6-14)22(29)24(31)20(23(21)30)26-32-18-8-4-7-17(27(34)35)25(18)33-26/h1-12H,13H2,(H,32,33)(H,34,35)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	378	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155479 (US9006454, I121) Show SMILES Cc1ccc(C)n1-c1ccc(cc1)-c1nc2cc(C)cc(C(O)=O)c2[nH]1 Show InChI InChI=1S/C21H19N3O2/c1-12-10-17(21(25)26)19-18(11-12)22-20(23-19)15-6-8-16(9-7-15)24-13(2)4-5-14(24)3/h4-11H,1-3H3,(H,22,23)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	401	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155416 (US9006454, I28) Show SMILES Cc1cc(C(O)=O)c2[nH]c(nc2c1)-c1ccc(cc1F)-c1ccccc1 Show InChI InChI=1S/C21H15FN2O2/c1-12-9-16(21(25)26)19-18(10-12)23-20(24-19)15-8-7-14(11-17(15)22)13-5-3-2-4-6-13/h2-11H,1H3,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	403	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155432 (US9006454, I59) Show SMILES Cc1cc(C(O)=O)c2nc([nH]c2c1)-c1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C20H15N3O2/c1-12-9-16(20(24)25)18-17(10-12)22-19(23-18)14-6-4-13(5-7-14)15-3-2-8-21-11-15/h2-11H,1H3,(H,22,23)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	407	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155431 (US9006454, I58) Show SMILES OC(=O)c1cc(F)cc2[nH]c(nc12)-c1ccc(cc1)-c1cccnc1 Show InChI InChI=1S/C19H12FN3O2/c20-14-8-15(19(24)25)17-16(9-14)22-18(23-17)12-5-3-11(4-6-12)13-2-1-7-21-10-13/h1-10H,(H,22,23)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	437	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155502 (US9006454, I144) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1c(F)c(F)c(-c2ccsc2)c(F)c1F Show InChI InChI=1S/C18H8F4N2O2S/c19-12-10(7-4-5-27-6-7)13(20)15(22)11(14(12)21)17-23-9-3-1-2-8(18(25)26)16(9)24-17/h1-6H,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	441	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155460 (US9006454, I102) Show SMILES Cc1cc(C(N)=O)c2nc([nH]c2c1)-c1c(F)c(F)c(-c2ccccc2)c(F)c1F Show InChI InChI=1S/C21H13F4N3O/c1-9-7-11(20(26)29)19-12(8-9)27-21(28-19)14-17(24)15(22)13(16(23)18(14)25)10-5-3-2-4-6-10/h2-8H,1H3,(H2,26,29)(H,27,28)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	446	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155406 (US9006454, I15) Show SMILES OC(=O)c1cccc2[nH]c(nc12)-c1ccc(cc1)-c1ccccc1F Show InChI InChI=1S/C20H13FN2O2/c21-16-6-2-1-4-14(16)12-8-10-13(11-9-12)19-22-17-7-3-5-15(20(24)25)18(17)23-19/h1-11H,(H,22,23)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	490	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155482 (US9006454, I124) Show SMILES OC(=O)c1cccc2nc([nH]c12)-c1c(F)c(F)c(-c2cccs2)c(F)c1F Show InChI InChI=1S/C18H8F4N2O2S/c19-12-10(9-5-2-6-27-9)13(20)15(22)11(14(12)21)17-23-8-4-1-3-7(18(25)26)16(8)24-17/h1-6H,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	500	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155401 (US9006454, I6) Show SMILES OC(=O)c1cc(Br)cc2[nH]c(nc12)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C20H13BrN2O2/c21-15-10-16(20(24)25)18-17(11-15)22-19(23-18)14-8-6-13(7-9-14)12-4-2-1-3-5-12/h1-11H,(H,22,23)(H,24,25)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem	US Patent	n/a	n/a	574	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155433 (US9006454, I61) Show SMILES OC(=O)c1cccc2cc([nH]c12)-c1ccc(cc1)-c1ccccc1 Show InChI InChI=1S/C21H15NO2/c23-21(24)18-8-4-7-17-13-19(22-20(17)18)16-11-9-15(10-12-16)14-5-2-1-3-6-14/h1-13,22H,(H,23,24)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	595	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155399 (US9006454, I3 | US9006454, I5) Show SMILES COc1cccc(c1)-c1ccc(-c2nc3c(cccc3[nH]2)C(O)=O)c(F)c1 Show InChI InChI=1S/C21H15FN2O3/c1-27-14-5-2-4-12(10-14)13-8-9-15(17(22)11-13)20-23-18-7-3-6-16(21(25)26)19(18)24-20/h2-11H,1H3,(H,23,24)(H,25,26)	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	616	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair
Dihydroorotate dehydrogenase (quinone), mitochondrial (Homo sapiens (Human))	BDBM155417 (US9006454, I29) Show SMILES OC(=O)c1cc(F)cc2[nH]c([nH]c12)-c1ccc(cc1F)-c1ccccc1 Show InChI	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	US Patent	n/a	n/a	623	n/a	n/a	n/a	n/a	8.0	n/a
Merck Serono S.A. US Patent					Assay Description The DHODH activity assay is a coupled enzyme assay in which oxidation of DHO and subsequent reduction of ubiquinone are stoichiometrically equivalent...				US Patent US9006454 (2015) BindingDB Entry DOI: 10.7270/Q2125RCJ
					More data for this Ligand-Target Pair

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