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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM287005 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Caliper-Based Kinase Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.600±n/a nM | ||
| Comments | extracted | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US9567334 Publication Date 2/14/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
| ||
| BDBM287005 | |||
| n/a | |||
| Name | BDBM287005 | ||
| Synonyms: | 8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((2-hydroxyethyl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 13 | US11078199, Cpd 13 | US9567334, Example 13 | US9815834, Compound 13 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H32Cl2N6O5 | ||
| Mol. Mass. | 591.486 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(NCCO)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |(2,8.47,;3.33,7.7,;3.33,6.16,;4.67,5.39,;4.67,3.85,;6,3.08,;7.34,3.85,;3.33,3.08,;3.33,1.54,;2,3.85,;2,5.39,;.67,6.16,;.67,3.08,;-.67,3.85,;-2,3.08,;-3.33,3.85,;-4.67,3.08,;-4.67,1.54,;-6,.77,;-6,-.77,;-7.34,-1.54,;-7.34,-3.08,;-3.33,.77,;-2,1.54,;-.67,.77,;-.67,-.77,;.67,-1.54,;.67,-3.08,;2,-3.85,;2,-5.39,;3.33,-6.16,;4.67,-5.39,;4.67,-3.85,;3.33,-3.08,;6,-6.16,;7.34,-5.39,;6,-7.7,;7.34,-8.47,;.67,1.54,;2,.77,)| | ||
| Structure | 
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