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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Fibroblast growth factor receptor 1 | ||
| Ligand | BDBM287015 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Caliper-Based Kinase Assay | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.700±n/a nM | ||
| Comments | extracted | ||
| Citation |  Verner, E; Brameld, KA Quinolone derivatives as fibroblast growth factor receptor inhibitors US Patent US9567334 Publication Date 2/14/2017 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Fibroblast growth factor receptor 1 | |||
| Name: | Fibroblast growth factor receptor 1 | ||
| Synonyms: | BFGFR | Basic fibroblast growth factor receptor 1 | Basic fibroblast growth factor receptor 1 (FGFR1) | CD_antigen=CD331 | CEK | FGFBR | FGFR-1 | FGFR-1 Tyrosine Kinase | FGFR-1, (FL) | FGFR1 | FGFR1_HUMAN | FLG | FLT2 | Fibroblast growth factor receptor (FGFR) | Fibroblast growth factor receptor 1 (FGFR-1) | Fibroblast growth factor receptor 1 (FGFR1) | Fms-like tyrosine kinase 2 | HBGFR | N-sam | VEGF-receptor 2 and Fibroblast growth factor receptor 1 | bFGF-R | c-fgr | ||
| Type: | Receptor | ||
| Mol. Mass.: | 91861.70 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P11362 | ||
| Residue: | 822 | ||
| Sequence: |
| ||
| BDBM287015 | |||
| n/a | |||
| Name | BDBM287015 | ||
| Synonyms: | (R)-8-(3-(4-acryloylpiperazin-1-yl)propyl)-6-(2,6-dichloro-3,5-dimethoxyphenyl)-2-((tetrahydrofuran-3-yl)amino)pyrido[2,3-d]pyrimidin-7(8H)-one | US10294223, Cpd No. 56 | US11078199, Cpd 56 | US9567334, Example 56 | US9815834, Compound 56 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C29H34Cl2N6O5 | ||
| Mol. Mass. | 617.523 | ||
| SMILES | COc1cc(OC)c(Cl)c(c1Cl)-c1cc2cnc(N[C@@H]3CCOC3)nc2n(CCCN2CCN(CC2)C(=O)C=C)c1=O |r,wD:19.19,(1.96,8.47,;3.29,7.7,;3.29,6.16,;4.62,5.39,;4.62,3.85,;5.96,3.08,;7.29,3.85,;3.29,3.08,;3.29,1.54,;1.96,3.85,;1.96,5.39,;.62,6.16,;.62,3.08,;-.71,3.85,;-2.04,3.08,;-3.38,3.85,;-4.71,3.08,;-4.71,1.54,;-6.05,.77,;-6.05,-.77,;-4.8,-1.68,;-5.28,-3.14,;-6.82,-3.14,;-7.29,-1.68,;-3.38,.77,;-2.04,1.54,;-.71,.77,;-.71,-.77,;.62,-1.54,;.62,-3.08,;1.96,-3.85,;1.96,-5.39,;3.29,-6.16,;4.62,-5.39,;4.62,-3.85,;3.29,-3.08,;5.96,-6.16,;7.29,-5.39,;5.96,-7.7,;7.29,-8.47,;.62,1.54,;1.96,.77,)| | ||
| Structure | 
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