| Reaction Details |
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 | Report a problem with these data |
| Target | Aurora kinase B |
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| Ligand | BDBM47238 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibitory Assay |
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| pH | 7.4±n/a |
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| IC50 | 90±n/a nM |
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| Comments | extracted |
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| Citation |  Hirai, H; Sootome, H Method for enhancing anti-tumor effect of a microtubule-targeting drug, and a method for treatment of tumor US Patent US9012475 Publication Date 4/21/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Aurora kinase B |
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| Name: | Aurora kinase B |
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| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
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| Type: | Protein |
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| Mol. Mass.: | 39327.72 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q96GD4 |
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| Residue: | 344 |
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| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
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| BDBM47238 |
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| n/a |
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| Name | BDBM47238 |
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| Synonyms: | US9012475, MLN8237 |
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| Type | n/a |
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| Emp. Form. | C27H20ClFN4O4 |
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| Mol. Mass. | 518.924 |
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| SMILES | COc1cc(Nc2ncc3CN=C(c4c(F)cccc4OC)c4c(Cl)cccc4-c3n2)ccc1C(O)=O |t:11| |
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| Structure | 
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