| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Aurora kinase B |
|---|
| Ligand | BDBM155567 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Inhibitory Assay |
|---|
| pH | 7.4±n/a |
|---|
| IC50 | 930±n/a nM |
|---|
| Comments | extracted |
|---|
| Citation |  Hirai, H; Sootome, H Method for enhancing anti-tumor effect of a microtubule-targeting drug, and a method for treatment of tumor US Patent US9012475 Publication Date 4/21/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Aurora kinase B |
|---|
| Name: | Aurora kinase B |
|---|
| Synonyms: | AIK2 | AIM-1 | AIM1 | AIRK2 | ARK2 | AURKB | AURKB_HUMAN | Aurora B kinase (aurB) | Aurora B-INCENP | Aurora kinase 2 | Aurora kinase B (AURKB) | Aurora-related kinase 2 | STK-1 | STK1 | STK12 | STK5 | Serine/threonine-protein kinase aurora B |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 39327.72 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | Q96GD4 |
|---|
| Residue: | 344 |
|---|
| Sequence: | MAQKENSYPWPYGRQTAPSGLSTLPQRVLRKEPVTPSALVLMSRSNVQPTAAPGQKVMEN
SSGTPDILTRHFTIDDFEIGRPLGKGKFGNVYLAREKKSHFIVALKVLFKSQIEKEGVEH
QLRREIEIQAHLHHPNILRLYNYFYDRRRIYLILEYAPRGELYKELQKSCTFDEQRTATI
MEELADALMYCHGKKVIHRDIKPENLLLGLKGELKIADFGWSVHAPSLRRKTMCGTLDYL
PPEMIEGRMHNEKVDLWCIGVLCYELLVGNPPFESASHNETYRRIVKVDLKFPASVPMGA
QDLISKLLRHNPSERLPLAQVSAHPWVRANSRRVLPPSALQSVA
|
|
|
|---|
| BDBM155567 |
|---|
| n/a |
|---|
| Name | BDBM155567 |
|---|
| Synonyms: | US10092556, Example 11 | US9012475, 11 | US9346787, 11 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H25ClFN5O4 |
|---|
| Mol. Mass. | 501.938 |
|---|
| SMILES | COc1ccc(CC2(CCN(CC2)C(=O)c2cccc(Cl)c2F)C(O)=O)nc1Nc1cc(C)[nH]n1 |
|---|
| Structure | 
|
|---|
Search and Browse
