| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Serine/threonine-protein kinase receptor R3 |
|---|
| Ligand | BDBM160273 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Flashplate Assay |
|---|
| IC50 | 2±n/a nM |
|---|
| Citation |  Klar, J; Vöhringer, V; Telser, J; Lobell, M; Süβmeier, F; Li, VM; Böttger, M; Golz, S; Lang, D; Schlemmer, K; Schlange, T; Schall, A; Fu, W Hydroxymethylaryl-substituted pyrrolotriazines as ALK1 inhibitors US Patent US9040691 Publication Date 5/26/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Serine/threonine-protein kinase receptor R3 |
|---|
| Name: | Serine/threonine-protein kinase receptor R3 |
|---|
| Synonyms: | ACVL1_HUMAN | ACVRL1 | ACVRLK1 | ALK1 | Activin receptor-like kinase 1 (ALK-1) | Serine/threonine-protein kinase receptor R3 (ALK1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 56134.46 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P37023 |
|---|
| Residue: | 503 |
|---|
| Sequence: | MTLGSPRKGLLMLLMALVTQGDPVKPSRGPLVTCTCESPHCKGPTCRGAWCTVVLVREEG
RHPQEHRGCGNLHRELCRGRPTEFVNHYCCDSHLCNHNVSLVLEATQPPSEQPGTDGQLA
LILGPVLALLALVALGVLGLWHVRRRQEKQRGLHSELGESSLILKASEQGDSMLGDLLDS
DCTTGSGSGLPFLVQRTVARQVALVECVGKGRYGEVWRGLWHGESVAVKIFSSRDEQSWF
RETEIYNTVLLRHDNILGFIASDMTSRNSSTQLWLITHYHEHGSLYDFLQRQTLEPHLAL
RLAVSAACGLAHLHVEIFGTQGKPAIAHRDFKSRNVLVKSNLQCCIADLGLAVMHSQGSD
YLDIGNNPRVGTKRYMAPEVLDEQIRTDCFESYKWTDIWAFGLVLWEIARRTIVNGIVED
YRPPFYDVVPNDPSFEDMKKVVCVDQQTPTIPNRLAADPVLSGLAQMMRECWYPNPSARL
TALRIKKTLQKISNSPEKPKVIQ
|
|
|
|---|
| BDBM160273 |
|---|
| n/a |
|---|
| Name | BDBM160273 |
|---|
| Synonyms: | US9040691, 1 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C16H18N4O |
|---|
| Mol. Mass. | 282.3403 |
|---|
| SMILES | CCCc1cc(-c2ccc(CO)cc2)c2c(N)ncnn12 |
|---|
| Structure | 
|
|---|
Search and Browse
