| Reaction Details |
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 | Report a problem with these data |
| Target | Smoothened homolog |
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| Ligand | BDBM163018 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Radioligand Competition Binding Assay |
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| Temperature | 298.15±n/a K |
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| IC50 | 66.2±n/a nM |
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| Comments | extracted |
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| Citation |  Nair, SK; Planken, SP Pyridine-2-derivatives as smoothened receptor modulators US Patent US9056865 Publication Date 6/16/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Smoothened homolog |
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| Name: | Smoothened homolog |
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| Synonyms: | G-protein- coupled-like receptor Smoothened (Smo) | SMO | SMOH | SMO_HUMAN | Smoothened homolog |
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| Type: | Protein |
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| Mol. Mass.: | 86415.51 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q99835 |
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| Residue: | 787 |
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| Sequence: | MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
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| BDBM163018 |
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| n/a |
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| Name | BDBM163018 |
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| Synonyms: | US9056865, A-145 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H25ClFN5O |
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| Mol. Mass. | 405.897 |
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| SMILES | CN(C)CC(=O)NC1CCN(CC1)c1cc(c(Cl)cn1)-c1ncc(F)cc1C |
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| Structure | 
|
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