Reaction Details | |||
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Report a problem with these data | |||
Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM166136 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.6±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
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BDBM166136 | |||
n/a | |||
Name | BDBM166136 | ||
Synonyms: | US9067937, 80 | ||
Type | Small organic molecule | ||
Emp. Form. | C26H28Cl2N4O2 | ||
Mol. Mass. | 499.432 | ||
SMILES | CN(C)[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)C1CC1 |r,wU:6.9,wD:3.2,(-2.06,5.23,;-2.46,3.74,;-3.95,3.35,;-1.37,2.66,;-1.77,1.17,;-.68,.08,;.81,.48,;1.21,1.96,;.12,3.05,;1.9,-.61,;1.9,-2.15,;3.23,-2.92,;3.23,-4.46,;1.9,-5.23,;.56,-4.46,;-.77,-5.23,;-2.1,-4.46,;-2.1,-2.92,;-.77,-2.15,;.56,-2.92,;-3.44,-2.15,;-3.44,-.61,;-4.77,.16,;-4.77,1.7,;-6.1,-.61,;-7.44,.16,;-6.1,-2.15,;-7.44,-2.92,;-4.77,-2.92,;4.56,-2.15,;4.56,-.61,;5.9,-2.92,;6.67,-4.26,;7.44,-2.92,)| | ||
Structure |