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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM166147 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 15±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
| ||
| BDBM166147 | |||
| n/a | |||
| Name | BDBM166147 | ||
| Synonyms: | US9067937, 91 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H21ClFN3O3 | ||
| Mol. Mass. | 429.872 | ||
| SMILES | CC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](O)CC1)-c1cc(F)c(O)c(Cl)c1 |r,wU:14.15,wD:17.19,(6.67,-2.18,;5.33,-1.41,;5.33,.13,;4,-2.18,;4,-3.72,;2.67,-4.49,;1.33,-3.72,;,-4.49,;-1.33,-3.72,;-1.33,-2.18,;,-1.41,;1.33,-2.18,;2.67,-1.41,;2.67,.13,;1.58,1.22,;.09,.82,;-1,1.91,;-.6,3.4,;-1.69,4.49,;.89,3.8,;1.98,2.71,;-2.67,-1.41,;-4,-2.18,;-5.33,-1.41,;-6.67,-2.18,;-5.33,.13,;-6.67,.9,;-4,.9,;-4,2.44,;-2.67,.13,)| | ||
| Structure | 
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