Reaction Details |
| Report a problem with these data |
Target | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
---|
Ligand | BDBM123687 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | Inhibition Assay |
---|
pH | 7.5±n/a |
---|
IC50 | >4000±n/a nM |
---|
Comments | extracted |
---|
Citation | Böss, F; Erb, C; Hendrix, M; Van Kampen, M; Wunder, F Selective phosphodiesterase 9A inhibitors as medicaments for improving cognitive processes US Patent US9067945 Publication Date 6/30/2015 |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
---|
Name: | High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A |
Synonyms: | High-affinity cAMP-specific and IBMX-insensitive 3 ,5 -cyclic phosphodiesterase 8A | PDE8A | PDE8A_HUMAN | Phosphodiesterase 8 | Phosphodiesterase 8 (PDE8) | Phosphodiesterase 8A (PDE8A) | Phosphodiesterase 8A (PDE8A1) | Phosphodiesterase 8A1 | Phosphodiesterase Type 8 (PDE8A) |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 93295.89 |
Organism: | Homo sapiens (Human) |
Description: | Recombinant catalytic domain (M1-E829) of human PDE8A. |
Residue: | 829 |
Sequence: | MGCAPSIHISERLVAEDAPSPAAPPLSSGGPRLPQGQKTAALPRTRGAGLLESELRDGSG
KKVAVADVQFGPMRFHQDQLQVLLVFTKEDNQCNGFCRACEKAGFKCTVTKEAQAVLACF
LDKHHDIIIIDHRNPRQLDAEALCRSIRSSKLSENTVIVGVVRRVDREELSVMPFISAGF
TRRYVENPNIMACYNELLQLEFGEVRSQLKLRACNSVFTALENSEDAIEITSEDRFIQYA
NPAFETTMGYQSGELIGKELGEVPINEKKADLLDTINSCIRIGKEWQGIYYAKKKNGDNI
QQNVKIIPVIGQGGKIRHYVSIIRVCNGNNKAEKISECVQSDTHTDNQTGKHKDRRKGSL
DVKAVASRATEVSSQRRHSSMARIHSMTIEAPITKVINIINAAQESSPMPVTEALDRVLE
ILRTTELYSPQFGAKDDDPHANDLVGGLMSDGLRRLSGNEYVLSTKNTQMVSSNIITPIS
LDDVPPRIARAMENEEYWDFDIFELEAATHNRPLIYLGLKMFARFGICEFLHCSESTLRS
WLQIIEANYHSSNPYHNSTHSADVLHATAYFLSKERIKETLDPIDEVAALIAATIHDVDH
PGRTNSFLCNAGSELAILYNDTAVLESHHAALAFQLTTGDDKCNIFKNMERNDYRTLRQG
IIDMVLATEMTKHFEHVNKFVNSINKPLATLEENGETDKNQEVINTMLRTPENRTLIKRM
LIKCADVSNPCRPLQYCIEWAARISEEYFSQTDEEKQQGLPVVMPVFDRNTCSIPKSQIS
FIDYFITDMFDAWDAFVDLPDLMQHLDNNFKYWKGLDEMKLRNLRPPPE
|
|
|
BDBM123687 |
---|
n/a |
---|
Name | BDBM123687 |
Synonyms: | US8741907, 3 | US9067945, 2 |
Type | Small organic molecule |
Emp. Form. | C17H26N4O |
Mol. Mass. | 302.4145 |
SMILES | CCC(CC)n1ncc2c1nc(CC1CCCCC1)[nH]c2=O |
Structure |
|