Target/Host (Institution) | Ligand | Target/Host Links | Ligand Links | Trg + Lig Links | Ki nM | ΔG° kJ/mole | IC50 nM | Kd nM | EC50/IC50 nM | koff s-1 | kon M-1s-1 | pH | Temp °C |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM119804 (US8691840, 7) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | <1 | <-47.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 0 |
Bayer Intellectual Property GmbH US Patent | Assay Description The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell... | US Patent US8691840 (2014) BindingDB Entry DOI: 10.7270/Q2M32TFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM119803 (US8691840, 5) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | <1 | <-47.1 | n/a | n/a | n/a | n/a | n/a | 7.4 | 0 |
Bayer Intellectual Property GmbH US Patent | Assay Description The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell... | US Patent US8691840 (2014) BindingDB Entry DOI: 10.7270/Q2M32TFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM119802 (US8691840, 2) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | 2 | -45.5 | n/a | n/a | n/a | n/a | n/a | 7.4 | 0 |
Bayer Intellectual Property GmbH US Patent | Assay Description The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell... | US Patent US8691840 (2014) BindingDB Entry DOI: 10.7270/Q2M32TFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM119805 (US8691840, 11) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 16 | -40.8 | n/a | n/a | n/a | n/a | n/a | 7.4 | 0 |
Bayer Intellectual Property GmbH US Patent | Assay Description The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell... | US Patent US8691840 (2014) BindingDB Entry DOI: 10.7270/Q2M32TFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Neuronal acetylcholine receptor subunit alpha-7 (Rattus norvegicus (Rat)) | BDBM119806 (US8691840, 15) | PDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD GoogleScholar AffyNet | PC cid PC sid UniChem | US Patent | 27 | -39.6 | n/a | n/a | n/a | n/a | n/a | 7.4 | 0 |
Bayer Intellectual Property GmbH US Patent | Assay Description The [3H]-methyllycaconitine binding assay is a modification of the method described by Davies et al. (Neuropharmacol. 1999, 38, 679-690). The P2 pell... | US Patent US8691840 (2014) BindingDB Entry DOI: 10.7270/Q2M32TFR | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | PDB MMDB KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 110 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | 720 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 7B (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-specific 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cAMP-specific 3',5'-cyclic phosphodiesterase 4B (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
Dual 3',5'-cyclic-AMP and -GMP phosphodiesterase 11A (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-dependent 3',5'-cyclic phosphodiesterase (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair | |||||||||||||
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Homo sapiens (Human)) | BDBM123687 (US8741907, 3 | US9067945, 2) | PDB MMDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt B.MOAD DrugBank antibodypedia GoogleScholar AffyNet | PC cid PC sid UniChem Similars | US Patent | n/a | n/a | >4.00E+3 | n/a | n/a | n/a | n/a | 7.5 | n/a |
Boehringer Ingehleim International GmbH US Patent | Assay Description The test substances are dissolved in 100% DMSO and serially diluted to determine their in vitro effect on PDE 9A. Typically, serial dilutions from 20... | US Patent US9067945 (2015) BindingDB Entry DOI: 10.7270/Q2708052 | |||||||||||
More data for this Ligand-Target Pair |