| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Acetylcholinesterase |
|---|
| Ligand | BDBM167914 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | Modified Ellman Assay |
|---|
| IC50 | 2.0e+3± 9e+1 nM |
|---|
| Citation |  Sang, ZP; Qiang, XM; Li, Y; Wu, B; Zhang, H; Zhao, MG; Deng, Y Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Chem Biol Drug Des86:1168-77 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Acetylcholinesterase |
|---|
| Name: | Acetylcholinesterase |
|---|
| Synonyms: | ACES_RAT | Acetylcholinesterase (AChE) | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | Acetylcholinesterase precursor | Acetylcholinesterase, AChE | Ache |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 68193.62 |
|---|
| Organism: | Rattus norvegicus (rat) |
|---|
| Description: | P37136 |
|---|
| Residue: | 614 |
|---|
| Sequence: | MRPPWYPLHTPSLASPLLFLLLSLLGGGARAEGREDPQLLVRVRGGQLRGIRLKAPGGPV
SAFLGIPFAEPPVGSRRFMPPEPKRPWSGILDATTFQNVCYQYVDTLYPGFEGTEMWNPN
RELSEDCLYLNVWTPYPRPTSPTPVLIWIYGGGFYSGASSLDVYDGRFLAQVEGTVLVSM
NYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFGESAGAASV
GMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGNDTEL
ISCLRTRPAQDLVDHEWHVLPQESIFRFSFVPVVDGDFLSDTPDALINTGDFQDLQVLVG
VVKDEGSYFLVYGVPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAVVLHYTDWLHPE
DPAHLRDAMSAVVGDHNVVCPVAQLAGRLAAQGARVYAYIFEHRASTLTWPLWMGVPHGY
EIEFIFGLPLDPSLNYTVEERIFAQRLMQYWTNFARTGDPNDPRDSKSPRWPPYTTAAQQ
YVSLNLKPLEVRRGLRAQTCAFWNRFLPKLLSATDTLDEAERQWKAEFHRWSSYMVHWKN
QFDHYSKQERCSDL
|
|
|
|---|
| BDBM167914 |
|---|
| n/a |
|---|
| Name | BDBM167914 |
|---|
| Synonyms: | N,N-diethylcarbamic acid-4-[6,7-bis(acetyloxy)-5-hydroxy-4-oxo-4H-1-benzopyran-2-yl]phenyl ester (7l) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C24H23NO9 |
|---|
| Mol. Mass. | 469.4407 |
|---|
| SMILES | CCN(CC)C(=O)Oc1ccc(cc1)-c1cc(=O)c2c(O)c(OC(C)=O)c(OC(C)=O)cc2o1 |
|---|
| Structure | 
|
|---|
Search and Browse
