| Reaction Details |
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 | Report a problem with these data |
| Target | Carboxylic ester hydrolase |
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| Ligand | BDBM167913 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Modified Ellman Assay |
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| IC50 | 5.03e+4± 6.8e+2 nM |
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| Citation |  Sang, ZP; Qiang, XM; Li, Y; Wu, B; Zhang, H; Zhao, MG; Deng, Y Design, synthesis, and biological evaluation of scutellarein carbamate derivatives as potential multifunctional agents for the treatment of Alzheimer's disease. Chem Biol Drug Des86:1168-77 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Carboxylic ester hydrolase |
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| Name: | Carboxylic ester hydrolase |
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| Synonyms: | Acetylcholinesterase and butyrylcholinesterase (AChE and BChE) | BuChE | Butyrylcholinesterase (BuChE) | butyrylcholinesterase precursor |
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| Type: | Enzyme |
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| Mol. Mass.: | 67776.22 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | n/a |
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| Residue: | 597 |
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| Sequence: | MVTEIHFLLWILLLCMLFGKSHTEEDVIITTKTGRVRGLSMPILGGTVTAFLGIPYAQPP
LGSLRFKKPQPLNKWPDVYNATKYANSCYQNIDQAFPGFQGSEMWNPNTNLSEDCLYLNV
WIPVPKPKNATVMVWVYGGGFQTGTSSLPVYDGKFLTRVERVIVVSMNYRVGALGFLAFP
GNSEAPGNMGLFDQQLALQWIQRNIAAFGGNPKSVTLFGESAGAASVSLHLLCPQSYPLF
TRAILESGSSNAPWAVKHPEEARNRTLTLAKFIGCSKENEKEIITCLRSKDPQEILLNEK
LVLPSDSIRSINFGPTVDGDFLTDMPHTLLQLGKVKTAQILVGVNKDEGTAFLVYGAPGF
SKDNDSLITRREFQEGLNMYFPGVSSLGKEAILFYYVDWLGDQTPEVYREAFDDIIGDYN
IICPALEFTKKFAELEINAFFYYFEHRSSKLPWPEWMGVMHGYEIEFVFGLPLERRVNYT
RAEEIFSRSIMKTWANFAKYGHPNGTQGNSTVWPVFTSTEQKYLTLNTEKSKINSKLRAP
QCQFWRLFFPKVLEITGDIDEREQEWKAGFHRWSNYMMDWKNQFNDYTSKKETCTDL
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| BDBM167913 |
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| n/a |
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| Name | BDBM167913 |
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| Synonyms: | N,N-diethylcarbamic acid-4-[5,6,7-tris(acetyloxy)-4-oxo-4H-1-benzopyran-2-yl]phenyl ester (7k) |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25NO10 |
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| Mol. Mass. | 511.4774 |
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| SMILES | CCN(CC)C(=O)Oc1ccc(cc1)-c1cc(=O)c2c(OC(C)=O)c(OC(C)=O)c(OC(C)=O)cc2o1 |
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| Structure | 
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