| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] |
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| Ligand | BDBM173587 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| pH | 6.8±n/a |
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| Ki | 3.8e+3±n/a nM |
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| IC50 | 1.04e+4± 6.5e+2 nM |
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| Comments | extracted |
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| Citation |  Radhakrishnan, S; Shimmon, R; Conn, C; Baker, A Development of hydroxylated naphthylchalcones as polyphenol oxidase inhibitors: Synthesis, biochemistry and molecular docking studies. Bioorg Chem63:116-22 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] |
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| Name: | Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] |
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| Synonyms: | PPO1 | PPO1_AGABI | Polyphenol oxidase (PPO) |
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| Type: | Protein |
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| Mol. Mass.: | 63874.81 |
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| Organism: | Agaricus bisporus (Mushroom) |
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| Description: | K9HG96 |
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| Residue: | 568 |
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| Sequence: | MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYP
LIPFNDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNK
SEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNPVNDG
GFYGPYNQWDTTLRQPDSTGVNAKDNVNRLTSVLKNAQASLTRATYDMFNRVTTWPHFSS
HTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAAFDPIFFLHHANVDRLIALWSAIR
YDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVG
LDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRLAKRSRLGQLLKGLF
SDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEI
GFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELT
DDEPNPRSRPPRYHKDITHGKRGGCREA
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| BDBM173587 |
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| n/a |
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| Name | BDBM173587 |
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| Synonyms: | (2E)-3-(3,5-dihydroxyphenyl)-1-(3-hydroxynaphthalen-2-yl)prop-2-en-1-one (5b) |
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| Type | Small organic molecule |
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| Emp. Form. | C19H14O4 |
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| Mol. Mass. | 306.3121 |
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| SMILES | Oc1cc(O)cc(\C=C\C(=O)c2cc3ccccc3cc2O)c1 |
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| Structure | 
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