| Reaction Details |
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 | Report a problem with these data |
| Target | Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] |
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| Ligand | BDBM50031467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzymatic Activity Assay |
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| pH | 6.8±n/a |
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| Ki | 1.22e+4±n/a nM |
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| IC50 | 2.75e+4± 5.6e+2 nM |
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| Comments | extracted |
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| Citation |  Radhakrishnan, S; Shimmon, R; Conn, C; Baker, A Development of hydroxylated naphthylchalcones as polyphenol oxidase inhibitors: Synthesis, biochemistry and molecular docking studies. Bioorg Chem63:116-22 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] |
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| Name: | Polyphenol oxidase 1 [N65D,S176D,K211T,P277A,P406L] |
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| Synonyms: | PPO1 | PPO1_AGABI | Polyphenol oxidase (PPO) |
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| Type: | Protein |
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| Mol. Mass.: | 63874.81 |
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| Organism: | Agaricus bisporus (Mushroom) |
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| Description: | K9HG96 |
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| Residue: | 568 |
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| Sequence: | MSHLLVSPLGGGVQPRLEINNFVKNDRQFSLYVQALDRMYATPQNETASYFQVAGVHGYP
LIPFNDAVGPTEFSPFDQWTGYCTHGSTLFPTWHRPYVLILEQILSGHAQQIADTYTVNK
SEWKKAATEFRHPYWDWASNSVPPPEVISLPKVTITTPNGQKTSVANPLMRYTFNPVNDG
GFYGPYNQWDTTLRQPDSTGVNAKDNVNRLTSVLKNAQASLTRATYDMFNRVTTWPHFSS
HTPASGGSTSNSIEAIHDNIHVLVGGNGHMSDPSVAAFDPIFFLHHANVDRLIALWSAIR
YDVWTSPGDAQFGTYTLRYKQSVDESTDLAPWWKTQNEYWKSNELRSTESLGYTYPEFVG
LDMYNKDAVNKTISRKVAQLYGPQRGGQRSLVEDLSNSHARRSQRLAKRSRLGQLLKGLF
SDWSAQIKFNRHEVGQSFSVCLFLGNVPEDPREWLVSPNLVGARHAFVRSVKTDHVAEEI
GFIPINQWIAEHTGLPSFAVDLVKPLLAQGLQWRVLLADGTPAELDSLEVTILEVPSELT
DDEPNPRSRPPRYHKDITHGKRGGCREA
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| BDBM50031467 |
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| n/a |
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| Name | BDBM50031467 |
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| Synonyms: | 5-HYDROXY-2-(HYDROXYMETHYL)-4H-PYRAN-4-ONE | 5-Hydroxy-2-hydroxymethyl-pyran-4-one | CHEMBL287556 | Kojic Acid | US10857082, Kojic acid | US9422261, Kojic acid | US9682910, kojic acid |
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| Type | Small organic molecule |
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| Emp. Form. | C6H6O4 |
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| Mol. Mass. | 142.1094 |
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| SMILES | OCc1cc(=O)c(O)co1 |
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| Structure | 
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