| Reaction Details |
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 | Report a problem with these data |
| Target | Thymidine phosphorylase |
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| Ligand | BDBM50019277 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Thymidine Phosphorylase Inhibition Assay |
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| pH | 7±n/a |
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| IC50 | 5.95e+4± 1.9e+3 nM |
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| Comments | extracted |
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| Citation |  Javaid, S; Saad, SM; Perveen, S; Khan, KM; Choudhary, MI 2-Arylquinazolin-4(3H)-ones: A novel class of thymidine phosphorylase inhibitors. Bioorg Chem63:142-51 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Thymidine phosphorylase |
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| Name: | Thymidine phosphorylase |
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| Synonyms: | TYPH_ECOSM | Thymidine phosphorylase (TP) | deoA |
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| Type: | Protein |
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| Mol. Mass.: | 47171.52 |
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| Organism: | Escherichia coli (Enterobacteria) |
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| Description: | B1LEI7 |
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| Residue: | 440 |
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| Sequence: | MFLAQEIIRKKRDGHALSDEEIRFFINGIRDNTISEGQIAALAMTIFFHDMTMPERVSLT
MAMRDSGTVLDWKSLHLNGPIVDKHSTGGVGDVTSLMLGPMVAACGGYIPMISGRGLGHT
GGTLDKLESIPGFDIFPDDNRFREIIKDVGVAIIGQTSSLAPADKRFYATRDITATVDSI
PLITASILAKKLAEGLDALVMDVKVGSGAFMPTYELSEALAEAIVGVANGAGVRTTALLT
DMNQVLASSAGNAVEVREAVQFLTGEYRNPRLFDVTMALCVEMLISGKLAKDDAEARAKL
QAVLDNGKAAEVFGRMVAAQKGPTDFVENYAKYLPTAMLTKAVYADTEGFVSEMDTRALG
MAVVAMGGGRRQASDTIDYSVGFTDMARLGDQVDGQRPLAVIHAKDENSWQEAAKAVKAA
IKLADKAPESTPTVYRRISE
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|
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| BDBM50019277 |
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| n/a |
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| Name | BDBM50019277 |
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| Synonyms: | 2-(2',5'-Dihydroxyphenyl)quinazolin-4(3H)-one (6) | CHEMBL3289119 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H10N2O3 |
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| Mol. Mass. | 254.2408 |
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| SMILES | Oc1ccc(O)c(c1)-c1nc2ccccc2c(=O)[nH]1 |
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| Structure | 
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