Reaction Details |
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Target | Protein Nef |
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Ligand | BDBM288036 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Measurement of Antiviral (HIV-1) Activity |
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Temperature | 298.15±n/a K |
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EC50 | 3.40±n/a nM |
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Comments | extracted |
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Citation | Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Protein Nef |
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Name: | Protein Nef |
Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef |
Type: | C-terminal core protein |
Mol. Mass.: | 23340.47 |
Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) |
Description: | P03406 |
Residue: | 206 |
Sequence: | MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC
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BDBM288036 |
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n/a |
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Name | BDBM288036 |
Synonyms: | US10087178, Example 17 |
Type | Small organic molecule |
Emp. Form. | C22H23ClFN3O5 |
Mol. Mass. | 463.887 |
SMILES | CCN1C(=O)c2c(O)c(=O)c(cn2C[C@@]11C[C@@H]1COC)C(=O)NCc1cccc(Cl)c1F |r| |
Structure |
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