Ki Summary

Reaction Details

Report a problem with these data

Target

Protein Nef

Ligand

BDBM288048

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Antiviral (HIV-1) Activity

Temperature

298.15±n/a K

EC50

5.30±n/a nM

Comments

extracted

Citation

Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018

More Info.:

Get all data from this article, Assay Method

Protein Nef

Name:

Protein Nef

Synonyms:

Type:

C-terminal core protein

Mol. Mass.:

23340.47

Organism:

Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)

Description:

P03406

Residue:

206

Sequence:

MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC

BDBM288048

n/a

Name

BDBM288048

Synonyms:

N-(2,4-difluorobenzyl)-9'- hydroxy-2'-isopropyl-trans- 3-(2-methoxyethoxy)-1',8'- dioxo-1',2'-3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazine]- 7'-carboxamide hydrochloride | US10087178, Example S8

Type

Small organic molecule

Emp. Form.

C25H29F2N3O6

Mol. Mass.

505.5111

SMILES

COCCO[C@H]1C[C@]2(C1)CN(C(C)C)C(=O)c1c(O)c(=O)c(cn21)C(=O)NCc1ccc(F)cc1F |r,wU:7.6,5.4,(9.34,-3.78,;8,-4.55,;6.67,-3.78,;5.33,-4.55,;4,-3.78,;4,-2.24,;2.91,-1.15,;4,-.07,;5.09,-1.15,;5.33,.7,;5.33,2.24,;6.67,3.01,;6.67,4.55,;8,2.24,;4,3.01,;4,4.55,;2.67,2.24,;1.33,3.01,;1.33,4.55,;,2.24,;-1.33,3.01,;,.7,;1.33,-.07,;2.67,.7,;-1.33,-.07,;-1.33,-1.61,;-2.67,.7,;-4,-.07,;-5.33,.7,;-5.33,2.24,;-6.67,3.01,;-8,2.24,;-9.34,3.01,;-8,.7,;-6.67,-.07,;-6.67,-1.61,)|

Structure