Ki Summary

Reaction Details

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Target

Protein Nef

Ligand

BDBM288057

Substrate/Competitor

n/a

Meas. Tech.

Measurement of Antiviral (HIV-1) Activity

Temperature

298.15±n/a K

EC50

20.0±n/a nM

Comments

extracted

Citation

Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018

More Info.:

Get all data from this article, Assay Method

Protein Nef

Name:

Protein Nef

Synonyms:

Type:

C-terminal core protein

Mol. Mass.:

23340.47

Organism:

Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B)

Description:

P03406

Residue:

206

Sequence:

MGGKWSKSSVVGWPTVRERMRRAEPAADGVGAASRDLEKHGAITSSNTAATNAACAWLEA
QEEEEVGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGLEGLIHSQRRQDILDLWIYHTQGY
FPDWQNYTPGPGVRYPLTFGWCYKLVPVEPDKVEEANKGENTSLLHPVSLHGMDDPEREV
LEWRFDSRLAFHHVARELHPEYFKNC

BDBM288057

n/a

Name

BDBM288057

Synonyms:

N-(2,4-difluorobenzyl)-2'- ethyl-trans-3,9'-dihydroxy- 1',8'-dioxo-1',2',3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazine]- 7'-carboxamide hydrobromide | US10087178, Example S17

Type

Small organic molecule

Emp. Form.

C21H21F2N3O5

Mol. Mass.

433.4053

SMILES

CCN1C[C@@]2(C[C@H](O)C2)n2cc(C(=O)NCc3ccc(F)cc3F)c(=O)c(O)c2C1=O |r,wU:4.4,6.6,(8.67,1.86,;7.34,2.63,;6,1.86,;6,.32,;4.67,-.45,;3.58,-1.54,;4.67,-2.63,;4.67,-4.17,;5.76,-1.54,;3.33,.32,;2,-.45,;.67,.32,;-.67,-.45,;-.67,-1.99,;-2,.32,;-3.33,-.45,;-4.67,.32,;-4.67,1.86,;-6,2.63,;-7.34,1.86,;-8.67,2.63,;-7.34,.32,;-6,-.45,;-6,-1.99,;.67,1.86,;-.67,2.63,;2,2.63,;2,4.17,;3.33,1.86,;4.67,2.63,;4.67,4.17,)|

Structure