Reaction Details | |||
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Target | Protein Nef | ||
Ligand | BDBM288071 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Measurement of Antiviral (HIV-1) Activity | ||
Temperature | 298.15±n/a K | ||
EC50 | 24.0±n/a nM | ||
Comments | extracted | ||
Citation | Miyazaki, S; Isoshima, H; Oshita, K; Kawashita, S; Nagahashi, N; Terashita, M Substituted spiropyrido[1,2-a]pyrazine derivative and medicinal use thereof as HIV integrase inhibitor US Patent US10087178 Publication Date 10/2/2018 | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein Nef | |||
Name: | Protein Nef | ||
Synonyms: | 3ORF | F-protein | HIV-1 Nef | NEF_HV1BR | Negative factor | Protein Nef | nef | ||
Type: | C-terminal core protein | ||
Mol. Mass.: | 23340.47 | ||
Organism: | Human immunodeficiency virus type 1 (isolate BRU/LAI group M subtype B) | ||
Description: | P03406 | ||
Residue: | 206 | ||
Sequence: |
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BDBM288071 | |||
n/a | |||
Name | BDBM288071 | ||
Synonyms: | N7'-(2,4-difluorobenzyl)-9'- hydroxy-2'-isopropyl-N3-N3- dimethyl-1',8'-dioxo- 1',2',3',8'- tetrahydrospiro[cyclobutane- 1,4'-pyrido[1,2-a]pyrazine]- cis-3,7'-dicarboxamide hydrochloride | US10087178, Example S31 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H28F2N4O5 | ||
Mol. Mass. | 502.5104 | ||
SMILES | CC(C)N1C[C@]2(C[C@@H](C2)C(=O)N(C)C)n2cc(C(=O)NCc3ccc(F)cc3F)c(=O)c(O)c2C1=O |r,wU:5.8,wD:7.9,(8.67,3.01,;7.34,3.78,;7.34,5.32,;6,3.01,;6,1.47,;4.67,.7,;5.76,-.39,;4.67,-1.47,;3.58,-.39,;4.67,-3.01,;6,-3.78,;3.33,-3.78,;2,-3.01,;3.33,-5.32,;3.33,1.47,;2,.7,;.67,1.47,;-.67,.7,;-.67,-.84,;-2,1.47,;-3.33,.7,;-4.67,1.47,;-4.67,3.01,;-6,3.78,;-7.34,3.01,;-8.67,3.78,;-7.34,1.47,;-6,.7,;-6,-.84,;.67,3.01,;-.67,3.78,;2,3.78,;2,5.32,;3.33,3.01,;4.67,3.78,;4.67,5.32,)| | ||
Structure |