Ki Summary

Reaction Details

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Target

Maternal embryonic leucine zipper kinase

Ligand

BDBM176948

Substrate/Competitor

n/a

Meas. Tech.

Kinase Assay

7.4±n/a

Temperature

298.15±n/a K

IC50

3.1±n/a nM

Comments

extracted

Citation

Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015

More Info.:

Get all data from this article, Assay Method

Maternal embryonic leucine zipper kinase

Name:

Maternal embryonic leucine zipper kinase

Synonyms:

KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)

Type:

Enzyme

Mol. Mass.:

74665.45

Organism:

Homo sapiens (Human)

Description:

Q14680

Residue:

651

Sequence:

MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV

BDBM176948

n/a

Name

BDBM176948

Synonyms:

US9120749, 314

Type

Small organic molecule

Emp. Form.

C30H36ClN3O3

Mol. Mass.

522.078

SMILES

CCN(CC)[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(OC)c1)C(=O)C1CC1 |r,wU:8.11,wD:5.4,(-4.37,3.89,;-3.28,2.8,;-1.79,3.2,;-1.39,4.69,;-2.48,5.78,;-.7,2.11,;-1.1,.62,;-.01,-.47,;1.48,-.07,;1.87,1.42,;.78,2.51,;2.56,-1.16,;2.56,-2.7,;3.9,-3.47,;3.9,-5.01,;2.56,-5.78,;1.23,-5.01,;-.1,-5.78,;-1.44,-5.01,;-1.44,-3.47,;-.1,-2.7,;1.23,-3.47,;-2.77,-2.7,;-2.77,-1.16,;-4.1,-.39,;-4.1,1.15,;-5.44,-1.16,;-6.77,-.39,;-5.44,-2.7,;-6.77,-3.47,;-8.11,-2.7,;-4.1,-3.47,;5.23,-2.7,;5.23,-1.16,;6.57,-3.47,;7.34,-4.8,;8.11,-3.47,)|

Structure