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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177252 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 4.2±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM177252 | |||
| n/a | |||
| Name | BDBM177252 | ||
| Synonyms: | US9120749, 618 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C31H36Cl2N4O2 | ||
| Mol. Mass. | 567.549 | ||
| SMILES | CN1CCN(C[C@H]2CC[C@@H](CC2)Nc2c(cnc3ccc(cc23)-c2cc(Cl)c(O)c(Cl)c2)C(=O)C2CC2)CC1 |r,wU:9.12,wD:6.5,(-3.44,6.93,;-3.44,5.39,;-2.1,4.62,;-2.1,3.08,;-3.44,2.31,;-3.44,.77,;-2.1,,;-2.1,-1.54,;-.77,-2.31,;.56,-1.54,;.56,,;-.77,.77,;1.9,-2.31,;1.9,-3.85,;3.23,-4.62,;3.23,-6.16,;1.9,-6.93,;.56,-6.16,;-.77,-6.93,;-2.1,-6.16,;-2.1,-4.62,;-.77,-3.85,;.56,-4.62,;-3.44,-3.85,;-4.77,-4.62,;-6.1,-3.85,;-7.44,-4.62,;-6.1,-2.31,;-7.44,-1.54,;-4.77,-1.54,;-4.77,,;-3.44,-2.31,;4.56,-3.85,;4.56,-2.31,;5.9,-4.62,;6.67,-5.95,;7.44,-4.62,;-4.77,3.08,;-4.77,4.62,)| | ||
| Structure | 
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