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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177334 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM177334 | |||
| n/a | |||
| Name | BDBM177334 | ||
| Synonyms: | US9120749, 700 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H30Cl2FN3O2 | ||
| Mol. Mass. | 530.461 | ||
| SMILES | Oc1c(Cl)cc(cc1Cl)-c1ccc2ncc(C(=O)C3CC3)c(N[C@H]3CC[C@H](CNCCF)CC3)c2c1 |r,wU:23.24,wD:26.28,(-7.44,.38,;-6.1,-.38,;-4.77,.38,;-4.77,1.93,;-3.44,-.38,;-3.44,-1.93,;-4.77,-2.69,;-6.1,-1.93,;-7.44,-2.69,;-2.1,-2.69,;-2.1,-4.23,;-.77,-5,;.56,-4.23,;1.9,-5,;3.23,-4.23,;3.23,-2.69,;4.56,-1.92,;4.56,-.38,;5.9,-2.69,;6.67,-4.03,;7.44,-2.69,;1.9,-1.93,;1.9,-.38,;.56,.38,;-.77,-.38,;-2.1,.38,;-2.1,1.93,;-3.44,2.69,;-3.44,4.23,;-4.77,5,;-6.1,4.23,;-7.44,5,;-.77,2.7,;.56,1.93,;.56,-2.69,;-.77,-1.92,)| | ||
| Structure | 
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