Reaction Details | |||
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Report a problem with these data | |||
Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM177340 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.1±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
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BDBM177340 | |||
n/a | |||
Name | BDBM177340 | ||
Synonyms: | US9120749, 706 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H27Cl2N5O2 | ||
Mol. Mass. | 536.452 | ||
SMILES | N[C@H]1CC[C@@H](CC1)n1cc(Nc2c(cnc3ccc(cc23)-c2cc(Cl)c(O)c(Cl)c2)C(=O)C2CC2)cn1 |r,wU:4.7,wD:1.0,(-2.5,6.68,;-2.1,5.19,;-3.19,4.1,;-2.79,2.61,;-1.3,2.22,;-.21,3.3,;-.61,4.79,;-.9,.73,;.56,.25,;.56,-1.29,;1.9,-2.06,;1.9,-3.6,;3.23,-4.37,;3.23,-5.91,;1.9,-6.68,;.56,-5.91,;-.77,-6.68,;-2.1,-5.91,;-2.1,-4.37,;-.77,-3.6,;.56,-4.37,;-3.44,-3.6,;-3.44,-2.06,;-4.77,-1.29,;-4.77,.25,;-6.1,-2.06,;-7.44,-1.29,;-6.1,-3.6,;-7.44,-4.37,;-4.77,-4.37,;4.56,-3.6,;4.56,-2.06,;5.9,-4.37,;6.67,-5.7,;7.44,-4.37,;-.9,-1.76,;-1.81,-.52,)| | ||
Structure |