Reaction Details | |||
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Report a problem with these data | |||
Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM177349 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.5±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
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BDBM177349 | |||
n/a | |||
Name | BDBM177349 | ||
Synonyms: | US9120749, 715 | US9120749, 716 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H31Cl2N3O2 | ||
Mol. Mass. | 500.46 | ||
SMILES | CCC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN(C)C)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:18.20,wD:15.16,(7.34,-1.92,;6,-2.69,;4.67,-1.93,;4.67,-.38,;3.33,-2.7,;3.33,-4.24,;2,-5.01,;.67,-4.24,;-.67,-5.01,;-2,-4.24,;-2,-2.7,;-.67,-1.93,;.67,-2.7,;2,-1.93,;2,-.39,;.67,.38,;.67,1.92,;-.67,2.69,;-2,1.92,;-3.33,2.69,;-3.33,4.23,;-4.67,5,;-2,5.01,;-2,.38,;-.67,-.38,;-3.33,-1.93,;-3.33,-.39,;-4.67,.38,;-4.67,1.92,;-6,-.39,;-7.34,.38,;-6,-1.93,;-7.34,-2.7,;-4.67,-2.7,)| | ||
Structure |