Reaction Details | |||
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Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM177373 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.3±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
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BDBM177373 | |||
n/a | |||
Name | BDBM177373 | ||
Synonyms: | US9120749, 739 | US9120749, 740 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H31Cl2N3O2 | ||
Mol. Mass. | 500.46 | ||
SMILES | CN(C)CC[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O |r,wU:5.4,wD:8.11,(-5.33,3.59,;-4,4.36,;-4,5.9,;-2.67,3.59,;-2.67,2.05,;-1.33,1.28,;,2.05,;1.33,1.28,;1.33,-.26,;,-1.03,;-1.33,-.26,;2.67,-1.03,;2.67,-2.82,;4,-3.59,;4,-5.13,;2.67,-5.9,;1.33,-5.13,;,-5.9,;-1.33,-5.13,;-1.33,-3.59,;,-2.82,;1.33,-3.59,;-2.67,-2.82,;-2.67,-1.28,;-4,-.51,;-4,1.03,;-5.33,-1.28,;-6.67,-.51,;-5.33,-2.82,;-6.67,-3.59,;-4,-3.59,;5.33,-2.82,;6.67,-3.59,;5.33,-1.28,)| | ||
Structure |