Reaction Details | |||
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Report a problem with these data | |||
Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM177387 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 1.5±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
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BDBM177387 | |||
n/a | |||
Name | BDBM177387 | ||
Synonyms: | US9120749, 753 | ||
Type | Small organic molecule | ||
Emp. Form. | C28H31Cl2N3O3 | ||
Mol. Mass. | 528.47 | ||
SMILES | CC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN2CCC(O)C2)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:17.19,wD:14.15,(6.67,-4.28,;5.33,-3.51,;5.33,-1.97,;4,-4.28,;4,-5.82,;2.67,-6.59,;1.33,-5.82,;,-6.59,;-1.33,-5.82,;-1.33,-4.28,;,-3.51,;1.33,-4.28,;2.67,-3.51,;2.67,-1.73,;1.33,-.96,;1.33,.58,;,1.35,;-1.33,.58,;-2.67,1.35,;-2.67,2.89,;-3.91,3.79,;-3.44,5.26,;-1.9,5.26,;-1.13,6.59,;-1.42,3.79,;-1.33,-.96,;,-1.73,;-2.67,-3.51,;-2.67,-1.97,;-4,-1.2,;-4,.34,;-5.33,-1.97,;-6.67,-1.2,;-5.33,-3.51,;-6.67,-4.28,;-4,-4.28,)| | ||
Structure |