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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177401 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
| ||
| BDBM177401 | |||
| n/a | |||
| Name | BDBM177401 | ||
| Synonyms: | US9120749, 767 | US9120749, 768 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C28H31Cl2N3O2 | ||
| Mol. Mass. | 512.471 | ||
| SMILES | CC(=O)c1cnc2ccc(cc2c1N[C@H]1CC[C@H](CN2CCCC2)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:14.15,wD:17.19,(6.67,-4.17,;5.33,-3.4,;5.33,-1.86,;4,-4.17,;4,-5.71,;2.67,-6.48,;1.33,-5.71,;,-6.48,;-1.33,-5.71,;-1.33,-4.17,;,-3.4,;1.33,-4.17,;2.67,-3.4,;2.67,-1.86,;1.58,-.77,;.09,-1.17,;-1,-.08,;-.6,1.41,;-1.69,2.5,;-1.29,3.99,;.17,4.46,;.17,6,;-1.29,6.48,;-2.2,5.23,;.89,1.81,;1.98,.72,;-2.67,-3.4,;-2.67,-1.86,;-4,-1.09,;-4,.45,;-5.33,-1.86,;-6.67,-1.09,;-5.33,-3.4,;-6.67,-4.17,;-4,-4.17,)| | ||
| Structure | 
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