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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM177451 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1.4±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM177451 | |||
| n/a | |||
| Name | BDBM177451 | ||
| Synonyms: | US9120749, 817 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H31Cl2N3O2 | ||
| Mol. Mass. | 500.46 | ||
| SMILES | CCN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(cc12)-c1cc(Cl)c(O)c(Cl)c1)C(C)=O |r,wU:5.4,wD:8.11,(-2.15,6.52,;-2.55,5.03,;-1.46,3.94,;.03,4.34,;-1.86,2.46,;-.77,1.37,;.72,1.77,;1.81,.68,;1.41,-.81,;-.08,-1.21,;-1.17,-.12,;2.5,-1.9,;2.5,-3.44,;3.83,-4.21,;3.83,-5.75,;2.5,-6.52,;1.16,-5.75,;-.17,-6.52,;-1.5,-5.75,;-1.5,-4.21,;-.17,-3.44,;1.16,-4.21,;-2.84,-3.44,;-2.84,-1.9,;-4.17,-1.13,;-4.17,.41,;-5.5,-1.9,;-6.84,-1.13,;-5.5,-3.44,;-6.84,-4.21,;-4.17,-4.21,;5.16,-3.44,;6.5,-4.21,;5.16,-1.9,)| | ||
| Structure | 
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