| Reaction Details |
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 | Report a problem with these data |
| Target | Maternal embryonic leucine zipper kinase |
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| Ligand | BDBM177546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Kinase Assay |
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| pH | 7.4±n/a |
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| Temperature | 298.15±n/a K |
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| IC50 | 0.94±n/a nM |
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| Comments | extracted |
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| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Huntley, R; Walker, JR; Decornez, H Quinoline derivatives and MELK inhibitors containing the same US Patent US9120749 Publication Date 9/1/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Maternal embryonic leucine zipper kinase |
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| Name: | Maternal embryonic leucine zipper kinase |
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| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) |
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| Type: | Enzyme |
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| Mol. Mass.: | 74665.45 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q14680 |
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| Residue: | 651 |
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| Sequence: | MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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| BDBM177546 |
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| n/a |
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| Name | BDBM177546 |
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| Synonyms: | US9120749, 913 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H25Cl2N5O3S |
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| Mol. Mass. | 558.479 |
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| SMILES | CS(=O)(=O)c1cnc2ccc(cc2c1Nc1ccc(nc1)N1CCCC(N)C1)-c1cc(Cl)c(O)c(Cl)c1 |
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| Structure | 
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